Cell: cpa2 Mavs regulates the pathogenicity of astrocytes through metabolism

Recently, researchers from Harvard Medical School and other scientific research institutions published an article entitled "metallic control of astrocyte pathogenic activity via cpa2 Mavs" on cell, and found that the organism cpa2 Mavs regulates the pathogenicity of astrocytes through metabolism Metabolism can regulate peripheral immunity, but its role in central nervous system (CNS) inflammation is poorly understood Through the combination of proteomics, metabonomics and transcriptomics, researchers found that sphingolipid metabolism in astrocytes caused the C2 domain of cytosolic phospholipase A2 (cpa2) and caspase recruitment domain of mitochondrial antiviral signaling protein (MAVs) Domain, card) interaction, activation of NF - κ B driven transcription program, promoting experimental autoimmune encephalomyelitis (EAE) and CNS inflammation in multiple sclerosis Cpa2 recruitment of Mavs destroys the interaction of mavs-hexokinase-2 (hK2), reduces the activity of HK enzyme and participates in the production of lactate to maintain the metabolism of neurons Meglut is a drug used to treat Gaucher's disease and Niemann peak's disease, which can inhibit the pathogenicity of astrocytes and improve EAE In this study, we found the immunometabolic mechanism of activating the activity of pro-inflammatory astrocytes, and analyzed the new role of Mavs in central nervous system inflammation, providing a potential target for treatment and intervention.