Cell: Chinese scientists have revealed for the first time a complete map of the proteomics of lung adenocarcinoma.

This article is for the original translational medicine network. Please indicate the source: Cathy introduction: lung cancer is one of the most malignant tumors that cause the fastest incidence rate and mortality rate and the most health and life threatening of the population.lung adenocarcinoma (luad) accounts for about half of the total lung cancer.recently, scientists from Chinese Academy of Sciences and other domestic institutions revealed the complete proteome map of lung adenocarcinoma for the first time in the world, providing valuable resources for the precise medical treatment of lung adenocarcinoma.although the genome research of lung adenocarcinoma (luad) has made remarkable progress in recent years, a large proportion of luad patients still lack targeted treatment strategies.and since proteins are the direct executors of life activities, a comprehensive proteomic study of luad can fill in the knowledge gap between genomic abnormalities and oncogenic protein functions.recently, scientists from Chinese Academy of Sciences and other domestic institutions revealed the complete proteome map of lung adenocarcinoma for the first time in the world, providing valuable resources for precise medical treatment of lung adenocarcinoma.through the comprehensive analysis of proteomics, phosphorylation proteomics, transcriptome and total exome sequencing data, this study revealed the molecular characteristics of luad, its association with clinical results, potential prognostic biomarkers and drug targets, and was published online in cell on July 9.the title is "integrated proteomic characterization of human lung adenocarcinoma". In order to fully understand the molecular structure of luad and provide the basis for more accurate diagnosis and treatment of luad, the scientists conducted proteomics and Phosphoproteomics analysis on tumor tissues and corresponding non cancerous adjacent tissues of 103 patients with luad.a total of 11119 proteins and 22564 phosphorylation sites were identified.combining these proteomic data with clinical and genomic data, a comprehensive molecular map of luad was obtained.Graphic Abstract scientists have found that epithelial mesenchymal transition and inflammatory and carcinogenic signaling pathways are likely to lead to poor prognosis of stage I luad.they further established a link between gene changes and proteomic characteristics in patients with EGFR or TP53 mutations, which are the two major driving genes in Chinese patients with luad.in patients with EGFR mutation, the expression levels of TTF-1 and napsin-a, as well as proteins in splicing bodies, were observed.in patients with TP53 mutation, a variety of carcinogenic pathways, including DNA replication and mismatch repair, have changed significantly.all patients were divided into three proteomic subtypes (S-I, S-II, s-iii), each with unique molecular and clinical characteristics.comprehensive bioinformatics analysis showed that S-I patients were associated with cell environment and good prognosis.in contrast, s-iii patients are associated with cell proliferation and proteomic stability, as well as poor prognosis. phosphoproteomic analysis further revealed the activated signaling pathways and kinases in different proteomic subtypes. the comprehensive analysis of proteomic and clinical data further revealed 27 potential plasma biomarkers and multiple drug targets of luad. among them, the researchers pointed out that HSP 90 β is one of the potential biomarkers and has been further verified in an independent cohort. this work provides new insights for luad research, which goes beyond the current genome research. for the first time in the world, Chinese scientists have carried out large-scale, high-throughput and systematic panoramic proteomics research on lung adenocarcinoma, and have established a complete map of luad in China at the level of genomics, transcriptomics, proteomics and phosphorylation proteomics. as a valuable and powerful resource, this proteome data set will accelerate the transformation of basic research into more accurate diagnosis and treatment in clinical practice. reference: [1] [2] ᦇ 20 recommended reading: fighting against epidemic situation, translational medicine network content team series report: [Nature] Liu Ruqian team makes another pioneering work! Development of mitochondrial gene editing tool for the first time! [Nature journal] the largest single cell RNA sequencing project in history! Discovery of glioblastoma stem cells for the first time is expected to inhibit cancer cells [Nature sub journal] British scientists discovered the Alzheimer's disease suppressor gene and developed a rapid drug testing platform [JAMA] large retrospective cohort study in the United States: statins can reduce the risk of cardiovascular disease and death in the elderly