Cell: cherish your goose bump, maybe it can help prevent baldness! Harvard scientists have found that the cells and nerves that cause goose bumps are also key to activating hair follicle stem cells. Scientific discoveries.

Let me start with a cold knowledge: in English, there is no chicken in the word "goose bumps", but it is called "goose bumps", just as there is not necessarily beef in beef noodles.[geese:? A fight? However, most of the world's languages are interlinked with Chinese in this word, and English is regarded as a different kind.in the Hebrew language of the Jews, if the same meaning is to be expressed as "duck goose bumps", I don't know what the scripture comes from.in English, why do you want to "persecute" geese? I can't tell you why, but there are so many unclear things in the world.after so many years of scientific development, the cause of goose bumps has not been clear before.to this question, the research team of Harvard University recently gave an absolutely unexpected answer: goose bumps are actually a way for the body to promote hair growth, because the same batch of cells, nerves and muscles that cause goose bumps also participate in the regulation of hair follicles! The study found that goose bumps are only a short-term response to cold stimulation.if the cold stimulation time is prolonged, the mechanism regulating the formation of goose bumps will activate hair follicle stem cells, thus accelerating hair growth and helping the human body keep warm [1]. The research was published in the recent "cell".so Multiple goose bumps, help prevent baldness? Hairline saved (photo: pixabay) how did scientists come up with such an explanation? This has to start with the patriarchal conjecture about the cause of goose bumps: in ancient times, when there were a lot of hair on the human body surface, goose bumps would make the hair stand up, thus playing a role in keeping warm. This kind of reflection is called "piloerection".but that was hundreds of thousands of years ago. Now it is estimated that, except for a few people, whose hair is erect will not be able to keep warm However, the mechanism of bristle reflex still remains and has not been eliminated by evolution, which indicates that it should have other effects on human body.the essence of the bristle reflex is the hair follicle bulge caused by the contraction of the hair follicle on the skin surface, which is controlled by the sympathetic nerve.however, scientific evidence has shown that sympathetic nerve plays a certain role in the regulation of human hair growth [2].the structure of small hair follicles is also very complicated (photo source: development, growth & amp; differentiation). Is it possible that the sympathetic nerve is busy behind the goose bumps, helping the human body to get more hair? The Harvard team, which carried out this study, first analyzed the regulation of sympathetic nerve on hair follicle stem cells.experiments show that the norepinephrine secreted by sympathetic nerve can directly affect the activity of hair follicle stem cells. Without norepinephrine, hair follicle stem cells are more likely to enter into dormancy state, with both eyes closed, regardless of hair.and if you give the mice more isoproterenol stimulation, it will speed up hair growth, this is not alopecia areata But in the experiment, hair follicle stem cells are too sensitive to norepinephrine, and very low levels of norepinephrine can activate them, which leads the research team to propose a new conjecture: can sympathetic nerve directly connect to hair follicle stem cells? The observation under the electron microscope confirmed this conjecture. The sympathetic nerve tightly surrounding the erector pilose muscle can also be connected to the hair follicle stem cells, and there are many connection sites. The relationship is not generally intimate.in the video, the blue one is the hair follicle, and the discolored one is the sympathetic nerve connected with the hair follicle. Further observation shows that there is a synaptic structure between the sympathetic nerve and the hair follicle stem cells, and the hair erector muscle is the necessary basis for the formation of this structure.these three kinds of cells are Trinity in the microstructure of skin hair follicles, which are indispensable for the appearance of goose bumps.stem cells, muscles and nerves are indispensable. When cold stimulation comes, the activity of sympathetic nerve is enhanced. At the same time, it can also secrete more norepinephrine, activate hair follicle stem cells and accelerate hair growth. compared with the control group without cold stimulation, the growth rate of mice in the continuous cold stimulation group was significantly faster, and the hair cycle was shortened to less than 2 weeks. in this process, there are also supporting roles such as β 2-adrenergic receptor. Interestingly, this process is just the opposite of hair follicle formation in the human growth and development stage: in the normal development process, hair follicle stem cells first appear, then hair erector muscles and sympathetic nerves finally arrive. hair follicle stem cells are required to secrete cytokines to regulate the structure formation of both erector pili muscle and sympathetic nerve. goose bumps are related to hair growth. The conclusion of this study is really interesting. in addition, the research team also proposed in the paper that a possible mechanism of hair loss includes the loss of hair erector muscle in the scalp, which leads to the decline of sympathetic nerve regulation ability, which makes hair follicle stem cells enter a dormant state and no longer produce hair. if we continue to dig this pathway, restore sympathetic regulation with adrenergic agonists, and reactivate hair follicle stem cells, will baldness be saved? Professor Ya Chieh Hsu, the corresponding author of the paper, said that the influence of external environment on skin stem cells will be her next research direction [3]. it's estimated that many people will say "hurry up, boss" when you see here, even the odd cake which has no worry about the hairline for the time being. by the way, although cold stimulation can promote hair growth, it is not recommended to freeze your head for this. 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