Cell Aging: A new compound that can effectively remove senescent cells and reduce toxic side effects of cancer therapy

, June 10, 2020 /PRNewswire/ -- The response of cells to damage and stress during aging is characterized by blocking of the cell cycle, when aging occurs, the cells will permanently stop dividing, thus allowing the continuous proliferation of cells that have been damaged and abnormally functional, however, eventually a large number of aging cells will accumulate in the tissues, leading to the occurrence and development of a variety of diseases, such as diabetes, cardiovascular disease, pulmonary fibrosis, and other diseasesIn addition, when cancer occurs, a variety of chemotherapy methods can lead to cell aging, and the accumulation of senescent cells due to this treatment is also directly related to tumor occurrence, but also directly related to the metastasis and recurrence of different types of cancer, which is why scientists are constantly looking for new drugs to remove cancer treatment induced cell aging, to ensure that the tumor is completely eradicated and effectively prevent cancer recurrencePicture Source: CC0 Public Domain
Longevity drug- senolytic drug is a compound that uses a variety of mechanisms to kill senescent cells, and it is a potentially replaceable treatment in the field of future oncology research, usually to treat other diseases associated with the accumulation of senescent cells, however, today senolytic drugs are less specific because they also damage healthy cells and have obvious toxic effects, potentially reducing their therapeutic effectiveness, in a recent study published in the international journal
aging cell, scientists from institutions such as the University of Political Science in Valencia, Spain, designed a second-generation senolytic drug that is more specific and less toxic, after researchers focused on a drug called Navitoclax, which in preclinical models has been shown to be effective in destroying aging cells and using acetylate-semi-eceratic to modify cell agingresearchers named the new senolytic drug Nav-Gal, which has a selective and extensive anti-aging activity that induces the death of aging cells and guarantees the activity of healthy cells, and researcher Professor Ramon Martinez Manez suggests combining semi-lactose with specific drugs as a universal approach to help develop a new generation of precursor drugs (prodrugs) with higher anti-aging activity and lower toxicityResearchers have now tested the therapeutic effects of the drug's combination chemotherapy (cisplatin) drug in human lung cancer cells, and it has been shown that cisplatin and Nav-Gal can completely eliminate aging lung cancer cells and significantly reduce tumor growth, and this study provides some evidence for the potential use of aging-induced chemotherapy with cancer anti-aging therapyIn addition, nav-Gal compounds reduce platelet toxicity and platelet reduction induced by the previously used drug Navitoclax(BioValley Bioon.com)original origins:Estela Gonz?lez-Gualda, Marta Pez-Ribes, Beatriz Lozano-Torres, et al.
Galacto-conjugation of Navitoclax as an san ei man-strategy to an senolytic tyity and a se
nolytic and a,Aging Cell(2020) DOI: 10.1111/acel.13142