Cell: A long-distance connection group that measures the brain on an all-brain scale.
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Last Update: 2020-07-29
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Source: Internet
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Author: User
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A new paper published online by Cell magazine recently uses DNA barcodes (DNA barcodes) and high-throughput sequencing techniques to solve the problem of mapping long-distance connectivity groups on an all-brain scaleThe article is entitled "BRICse bridges brain-wide interregional connectivity to the activity y gene expression in single animals"Researchers at Cold Spring Harbor Laboratory used a large number of unique and diverse nucleic acid barcodes to mark and track long-range projection of individual neurons, calling it BRICseq technologyCompared with the limitation of the number of colors that can be used and accurately detected in traditional technology, nucleic acid molecules are not only theoretically infinitely diverse, but can be detected by high-throughput, high-reliability sequencing technology, thus greatly improving the mapping flux of long-distance connection groupsIn addition, the combination of BRICseq and other whole-brain scale measurement gene expression groups, experimental techniques of brain activity and behavioral experiments will enable the experimenters to systematically and integrate the gene expression, connection patterns, neural activity and behavioral characteristics of individual animals, thus exploring the scientific principles of the structure and function of the brain()
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