CDSR: medical research reveals the best time for men and women to receive HPV vaccine

November 24, 2019 / bioun / -- recently, new evidence published by Cochrane Library provides more information about the advantages and disadvantages of different human papillomavirus (HPV) vaccines and the vaccination schedule for boys and girls According to who statistics in 2017, HPV is the most common reproductive tract virus infection in the world Most people who have sex will be infected with HPV throughout their lives It's just that for most people, their own immune system spontaneously clears out HPV infection (image source: www Pixabay Com) if the immune system is unable to clear the virus, HPV infection will persist Persistent infection of some "high-risk" HPV strains can lead to the development of cancer High risk HPV strains can cause all cervical and anal cancers, as well as some vaginal, vulvar, anal, penile, and head and neck cancers Other "low-risk" HPV strains can cause condyloma acuminatum, but not cancer HPV is first associated with a condition called "intraepithelial neoplasia" before causing cancer In serious cases, one third of the lesions will eventually develop into cervical cancer In 2012, HPV related cancers accounted for about 4.5% of global cancers The goal of vaccination is to prevent future HPV infection and cancer caused by high-risk HPV infection HPV vaccine is mainly targeted at adolescent girls, because cervical cancer is the most common HPV related cancer In order to prevent cervical cancer, the World Health Organization recommends that girls aged 9-14 be vaccinated against HPV The most effective strategy is to divide the vaccine into two doses (0, 6 months) Three doses are recommended for girls under 15 years of age or for people with human immunodeficiency virus (HIV) infection or other causes of immunodeficiency Currently, three kinds of HPV vaccines are being used: bivalent vaccine for the two most common types of high-risk HPV; bivalent vaccine for four types of HPV and bivalent vaccine for nine types of HPV For women who are not naturally infected with HPV, bivalent and bivalent vaccines have been shown to work well The Cochrane review summarizes the results of 20 randomized controlled trials involving 31940 people across continents In most studies, the indicator of vaccine protection effectiveness is the HPV antibody produced by the immune system of vaccinators Four studies compared the two dose and three dose regimens of 2317 adolescent girls, and three compared the different time intervals between the first two doses in 2349 girls and boys The results showed that for girls, two and three doses of HPV vaccine produced similar protective antibody responses When the interval between the first two injections of HPV vaccine is longer, boys and girls have stronger antibody response A study of men between the ages of 16 and 26 showed that a tetravalent HPV vaccine reduced the incidence of external genital lesions and genital warts compared with people who were not vaccinated with HPV vaccine A study of 16 - to 26 year olds also found that nine - and four price vaccines have similar levels of protection against precancerous lesions of the cervix, vagina and vulva Up to 90% of men and women who received HPV vaccine experienced local mild adverse events such as redness, swelling and pain at the injection site Dr Jo Morrison, chief editor of the review and consultant of gynecological oncology at Musgrove Park Hospital in Somerset, UK, said: "we need to conduct a long-term population-based study to provide data on the interval of administration, schedule and vaccine efficacy However, with similar antibody responses in reduced doses and more extensive evidence from vaccine research for boys, decision makers can now better design vaccination plans " Sources of information: assessing different HPV vaccines and vaccine schedules in advisory girls and boys original sources: Hanna Bergman, Brian s Buckley, Gemma Villanueva, Jennifer Petkovic, Chantelle Garrity, Vittoria lutje, Alina ximena rivers Balta, Nicola low, Nicholas Henschke Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV-related disease in females and males Cochrane Database of Systematic Reviews, 2019; DOI: 10.1002/14651858.CD013479