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Cardiovasc Diabetol: Sodium-sugar cotransporter inhibitor can significantly reduce the risk of cardiovascular events in patients with T2DM

 Last Update: 2021-07-27
 Source: Internet
 Author: User

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About Type 2 diabetes mellitus (T2DM) patients prospectively heart blood vessels results (CV) outcome trials support the use of sodium - glucose cotransporter 2 inhibitor (SGLT2i) T2DM patients to reduce cardiovascular event risk
.

Diabetes, heart blood vessel using sodium - glucose cotransporter 2 inhibitor (SGLT2i) T2DM patients to reduce cardiovascular event risk for cardiovascular events

The CVD-REAL Catalonia trial is a retrospective cohort study that uses real-world data collected daily from 2013 to 2016 to compare SGLT2i and other new users of hypoglycemic drugs (oGLD).
The risk of vascular events
.

According to the propensity score, new users of matched SGLT2i and oGLD were included in a ratio of 1:1
.
The incidence and risk ratio (HR) of all-cause mortality, heart failure hospitalization, chronic kidney disease, and adjusted major adverse CV events (MACE; all-cause mortality, myocardial infarction or stroke ) were compared

Heart failure myocardial infarction stroke

The occurrence of various outcomes of the two groups of subjects

After matching the propensity scores, each group included 12,917 new users
.
About 27% of the subjects had a history of cardiovascular disease

Each group included 12,917 new users with SGLT2i use and lower heart failure (HR 0.

Original source:

Real, J.

Cardiovascular and mortality benefits of sodium--glucose co-transporter-2 inhibitors in patients with type 2 diabetes mellitus: CVD-Real Catalonia.
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