Can't lose fat?

Can't lose fat? Blame your gut microbiota

Can't lose fat? Is it to blame your gut microbiota for not losing fat? Blame your gut microbiota

Science and Technology Daily, Beijing, September 16 (Reporter Zhang Mengran) According to a new study, the most closely related factor for the success or failure of weight loss is the gut microbiota, which has nothing to do with body mass index (BMI)
.

The results of the study were published this week in the open access journal "mSystems" of the American Society for Microbiology

The lead author of the study, Dr.
Christian Diner, a scientist at the Seattle Institute of Systems Biology, said: "Your gut microbiota can help or cause resistance to weight loss.
This opens up attempts to influence weight loss by changing the gut microbiota.
Possibility
.

"

In this study, Dr.
Diner and colleagues focused on a large group of people involved in lifestyle intervention research
.

This intervention is not a specific diet or exercise plan, but involves a business behavior coaching plan, supplemented by the advice of nutritionists, nurses, and coaches

The researchers analyzed the blood metabolites, blood proteins, diet questionnaires and intestinal bacteria of the two groups
.

They identified 31 baseline fecal metagenomic features related to weight loss responses, including complex polysaccharide and protein degradation genes, stress response genes, respiratory-related genes, cell wall synthesis genes, and intestinal bacterial replication rates

Studies have found that the microbiome of weight-loss people has a higher rate of bacterial growth and is rich in genes that transfer dietary nutrients to bacterial cell growth
.

In contrast, the microbiome that is resistant to weight loss has a lower growth rate and is more capable of breaking down non-absorbable fiber and starch into absorbable sugar

This result emphasizes the fact that the gut microbiota is an important filter between the food consumed by the human body and the blood
.

Weight loss can be particularly difficult when intestinal bacteria slow their own growth, while also breaking down dietary fiber into energy-rich sugars that enter the human blood before being fermented by the microbiota into organic acids

More importantly, the team studied the determinants of successful weight loss that have nothing to do with BMI
.

People with a higher baseline BMI tend to lose more weight after receiving the intervention, a situation known as the "return to mean" effect

Researchers have found that certain bacteria (Prlovella and other Bacteroides) seem to use degradation products from complex starch and fiber more effectively to promote growth, and may outperform the body in the competition of these energy-rich small molecules, and Reduce the caloric food gained from consumption
.

Ensuring that gut microbes can effectively convert sugars isolated from dietary fiber into short-chain fatty acids and/or reducing the abundance of bacterial fiber degradation genes in the intestine may help ensure improved weight loss responses to lifestyle interventions and better Metabolic health