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Cancers: Transarterial radioembolization (TARE) is safe and effective in the treatment of unresectable hepatocellular carcinoma (HCC)

 Last Update: 2022-02-20
 Source: Internet
 Author: User

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Hepatocellular carcinoma is one of the most common causes of cancer death in the world, and transarterial radioembolization (TARE) has been widely used in the treatment of hepatocellular carcinoma

From 2008 to 2014, a total of 149 HCC patients treated with TARE were included

Objective response was observed in 67 (45.

Median OS and PFS were 18.

OS and PFS

The median OS of patients in CTP group A was significantly better than that in group B (21.

OS subgroup analysis

Similar results were observed in PFS, with CTP A patients having a better median PFS than CTP B patients (9.

PFS subgroup analysis

Statistically significant median OS (41.

Statistically significant median OS (41.
9 months vs.
11.
6 months, p<0.
001) and PFS (22 months vs.
4.
6 months, p<0.
001) in responders (CR and PR) versus non-responders learning differences
.
Statistically significant median OS (41.
9 months vs.
11.
6 months, p<0.
001) and PFS (22 months vs.
4.
6 months, p<0.
001) in responders (CR and PR) versus non-responders learning differences
.

Differences in OS and PFS with and without response

Complications occurred in 60 patients (40.
3%); of these, grade 3 adverse events (AEs) occurred in 4 patients within 7 days after TARE
.
Because patients may have multiple AEs, there were 123 cases according to toxicity grading, grade 1/2 AEs accounted for 91.
1% of total AEs, and grade 3 AEs accounted for 8.
9%
.
The most common grade 1/2 AEs were gastrointestinal symptoms such as abdominal pain, nausea, anorexia, fatigue, and diarrhea
.
Grade 3 AEs included nausea, anorexia, improvement in abdominal pain without sequelae and other AEs (cholecystitis, sepsis, celiac dissection, and HCC rupture)
.

Adverse reactions

In conclusion, studies have shown that transarterial radioembolization (TARE) is safe and effective in the treatment of unresectable hepatocellular carcinoma (HCC)
.

In conclusion, studies have shown that transarterial radioembolization (TARE) is safe and effective in the treatment of unresectable hepatocellular carcinoma (HCC)
.
Studies have shown that transarterial radioembolization (TARE) is safe and effective in the treatment of unresectable hepatocellular carcinoma (HCC)
.
Studies have shown that transarterial radioembolization (TARE) is safe and effective in the treatment of unresectable hepatocellular carcinoma (HCC)
.

Original source:

Yim, SY; Chun, HS; Lee, JS; Lim, J.
-H.
; Kim, TH; Kim, BK; Kim, SU; Park, JY; Ahn, SH; Kim, GM; et al.
Transarterial Radioembolization for Unresectable Hepatocellular Carcinoma: Real-Life Efficacy and Safety Analysis of Korean Patients.
Cancers 2022, 14, 385.
https://doi.
org/10.
3390/cancers14020385

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