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Image: Optimal osmotic pressure and viscosity range (blue area)
for anticancer drug solvents for lymphatic delivery.
It is suitable for all types of cancer
.
Cancer is a general term
for diseases characterized by the uncontrolled growth of tumor cells.
Often, these tumor cells invade and colonize neighboring organs, causing what is clinically known as metastasis
.
Once a lymph node is infiltrated by tumor cells, its surroundings are filled with a variety of abnormalities
.
These abnormalities constitute many barriers to drug transport that prevent effective treatment
.
Traditional intervention strategies have not addressed the challenges
of metastatic lymph node treatment.
The lymphatic drug delivery system (LDDS) is a promising therapeutic
intervention for metastatic lymph nodes.
LDDS is the injection of drugs directly into sentinel lymph nodes under ultrasound guidance to elicit a powerful anti-tumor response
.
It was established under the leadership of Professor Tetsuya Kodama of the Graduate School of Medical Engineering at Tohoku University in Japan as an alternative to
current drug delivery strategies.
Now, Prof.
Kodama and a collaborative group have developed a new drug formulation that, when administered using LDDs, can enhance the therapeutic response
of carboplatin.
Carboplatin is a commercially available anti-cancer drug
.
The team includes doctoral student Radhika Mishra, also from Tohoku's Graduate School of Medical Engineering, collaborating
with Dr.
Kiyoto Shiga of Iwate Medical University Hospital and Dr.
Arun Kumar Dorai of Tohoku University's Institute of Advanced Materials.
The formula contains polysorbate and has a high osmotic pressure and viscosity (1897 kPa, 11.
5 mPa·s)
relative to brine.
This allows it to well alter the lymph node environment, increase the penetration of the drug into metastases, and amplify the antitumor effect
of the drug.
"Our work outlines the key variables that influence the response to drug therapy delivered by LDDS and highlights the importance of
developing a multi-pronged approach to develop effective anti-cancer strategies," Kodama said.
