Cancer Res: Reveals the molecular mechanisms by which ovarian cancer grows and evolves in the body.

11, 2020 // In a recent study published in the international journal Cancer Research, scientists from the City University of New York and other institutions have revealed the molecular mechanisms by which ovarian cancer grows and evolves in the human body.
the study entitled "Multi-omic analysis of the subtype evolution and heterogeneity in high-grade serous ovarian carcinoma" has some basic scientific significance, in which the researchers present their own decades-long insightinto into the process of tumor development and the practical implications of these ideas for the development of cancer subtype targeted therapies.
Photo Credit: Nephron/Wikipedia. CC BY-SA 3.0 more than 20,000 women in the U.S. are diagnosed with ovarian cancer each year, and about 14,000 people die; researcher Waldron says it is difficult to understand the mechanisms of heterogeneous tumor evolution before diagnosis because we can't directly observe tumor evolution, but by looking at tumors found at different stages of evolution, and on the genomic properties of tumors and the genome of tumors A detailed study of heterogeneity may allow researchers to capture something new; now researchers want to know whether tumors start with a particular subtype and sustain it, or evolve, change, and even reproduce over time; and if a tumor subtype evolves and reproduces in a tumor, special treatments for tumor subtypes seem unlikely to help. to answer this question
, in this study, researchers developed a new way to infer the presence of heterogeneous tumor subtypes from complementary types of genomic data, and they can solve the same problems using complementary but complete different approaches, one of which uses traditional methods to sequence DNA and RNA in large numbers of tumor tissue, and the other that allows new single-cell sequencing analysis of a portion of tumors;
a result that surprised the researchers, rejecting the idea of a discrete transcription subtype of the cancer and replacing it with a continuous tumor model, including a mixture of subclonals, the accumulation of mutations, the immersion of immune cells and matrix cells (whose proportions are related to tumor stages and the origin tissue), as well as the evolutionary properties associated with the previous discrete subtypes; Unfortunately, previous researchers' views on discrete subtypes are too simplistic and may not help us understand the pathogenesis of disease, prevention, and treatment of diseases; fortunately, with scientists gaining a clearer understanding of tumor heterogeneity and the rapid development of tumor heterogeneous technologies, future researchers may be more likely to understand the causes of tumor heterogeneity and develop targeted anti-cancer therapies. original origins from
: Ludwig Geistlinger, Sehyun Oh, Marcel Ramos, et al, . Multi-omic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinoma, Cancer Research (2020). doi: 10.1158/0008-5472.CAN-20-0521.