Cancer Res: Platelets can prevent cancer cell metastasis!

, July 6, 2020 /PRNewswire-bio-valley s/
scientists at Uppsala University have discovered a so-yet-unknown function of platelets in cancerIn mouse models, these platelets have been shown to help protect the vascular barrier, making the walls of blood vessels selectively impermeable, thereby reducing the spread oftumorscells to other parts of the bodyThe study was published in the journal Cancer Researchplatelets are tiny cell fragments that form in the bone marrow and circulate in the bloodIf we get hurt and start bleeding, they come together, close the wound, and also help the blood clotwhen platelets are activated -- not only in the wound, but also intumor-- the growth factor substances contained in platelets are released into the surrounding environmentOne of these is platelet-derived growth factor B (PDGFB)photo source: Yanyu Zhang
In this study, researchers investigated what happens in cancer individuals when PDGFB (not found in other cell types) in platelets is removedPDGFB in platelets is essential in attracting supporting cells into tumor blood vesselsOn the other hand, in healthy tissues, platelets do not perform this function If pDGFB is lacking in platelets, circulating tumors the number of cells increaseand spread to other parts of the body previous studies have shown that PDGFB comes from another cell, endothelial cells arranged inside blood vessels, and when it supports cell formation, PDGFB is necessary to attract support cells into blood vessels According to the new study, this function also requires platelet-provided PDGFB in tumors, the cells responsible for separating tumor from healthy tissue from a medical point of view, in some cases, such as to prevent blood clots, reducing platelet activity may be beneficial In addition, previous studies have shown that platelets can promote the spread of cells tumors "Our data show that platelet activation is not completely harmful to cancer In contrast, PDGFB, which releases when platelets are activated, can help maintain the vascular barrier in the tumor, thereby inhibiting the spread of tumors cells "This makes it important to consider the specific functions of different platelet-derived molecules when developing new therapies," said Anna-Karin Olsson, head of a research team in the Department of Medical Biochemistry and Microbiology at Uppsala University " (biovalleybioon.com) references: Novel function of platelets in blood tumor s found Zhang et al., Platelet-specific PDGFB ablation-the-cs- scorpifs scorpion and promotes metastasis, Cancer Research (2020) DOI: 10.1158/0008-5472.CAN-19-3533