Cancer: Nemotto bead singofa vs. simple cisplatin radiotherapy treatment of local advanced head and neck cancer effect
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Last Update: 2020-07-13
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Source: Internet
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Author: User
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In a Phase 2 study, adding nimottozumab to chemotherapy in patients with local advanced head and neck cancer improved efficacy, so a phase 3 study was conducted to confirm these findingsthe open-label, researcher-led phase 3 randomized trial was conducted between 2012 and 2018Adult patients with local advanced head and neck cancer with stativative chemotherapy received 1:1 random lysis (66-70 g) and used cisplatin (30mg/m2) (CRT) or CRT per week with the same protocol as weekly use of nemottozumab (200mg) (NCRT)The primary endpoints are progression-free survival (PFS); In addition, the researchers conducted an analysis of intentional therapyresults, a total of 536 patients were assigned to two treatment arms on an average equal shareMedian follow-up time was 39.13 monthsAdding nemottobead smoreactor improves PFS (danger ratio (HR), 0.69; 95% CI, 0.53-0.89; P06) and DFS (HR, 0.71; 95% CI, 0.55-0.92; PLevel 3 to 5 adverse events are similar between 2 arms, except for the higher incidence of mucositis in NCRT arms (66.7% vs 55.8% ;P, the results show that adding nimottozumab to the simultaneous weekly CRT improves PFS, LRC and DFSThis combination provides a new alternative treatment for patients with local advanced head and neck cancer with root-and-end CRT treatment, which can replace a 3-week solution of 100 mg/m2 cisplatin
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