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Exosomes are important mediators of cell-to-cell communication because of their ability to transport proteins and RNAs between cells, and due to their tumor-targeting ability, immune compatibility, lower toxicity, and longer half-life, Stem cell- derived exosomes may be expected to help scientists develop novel anti-tumor strategies
Exosomes are important mediators of cell-to-cell communication because of their ability to transport proteins and RNAs between cells, and due to their tumor-targeting ability, immune compatibility, lower toxicity, and longer half-life, Stem cell- derived exosomes may be expected to help scientists develop novel anti-tumor strategies
Recently, in a research report titled "Evaluating adipose-derived stem cell exosomes as miRNA drug delivery systems for the treatment of bladder cancer" published in the international journal Cancer Medicine , scientists from Nanjing University School of Medicine and other institutions in China passed the study.
Special exosome molecules may improve the transport efficiency of anticancer drugs to tumors
Special exosome molecules may improve the transport efficiency of anticancer drugs to tumors
In this study, the researchers used exosomes produced by specialized cells called lipid-derived mesenchymal stem cells (ADSCs) to deliver RNA-based (miR-138-5p) Anticancer therapy, which effectively treats bladder cancer in mice
Exosome-transported miR-138-5p may effectively prevent the migration, invasion and proliferation of bladder cancer cells in vitro.
Original source:
Tianyao Liu, Tianhang Li, Yufeng Zheng, et al.
Tianyao Liu, Tianhang Li, Yufeng Zheng, et al.
Evaluating adipose-derived stem cell exosomes as miRNA drug delivery systems for the treatment of bladder cancer ,Cancer Medicine(2022).
DOI: 10.
1002/cam4.
4745 Evaluating adipose-derived stem cell exosomes as miRNA drug delivery systems for the treatment of bladder cancer Cancer Medicine