Cancer Cell: Significant progress, Wang Jia/Li Kai/Dong Rui's first analysis of the single-cell map of neuroblastoma.

Neuroblastoma (NB) is a subtype of neuro-derived malignancies and is the most common extracranial solid tumor in childhood.
extensive research, the potential origin of NB remains unclear.
September 17, 2020, Fudan University's Li Kai, Dong Rui and Shanghai Jiaofu University's Wang Jia co-communications and Coancer Cell published online a research paper entitled Single-Cell Characteration of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma, using Single-cell RNA sequencing produced adrenal NB transcription groups from 160,910 cells in 16 patients and a transcription group of presumed developmental cells of NB origin from 12,103 cells in early human embryos and fetal adrenal glands at a relatively early stage of development.
study found that most adrenal NB tumor cells transprine mirror-imaged epinephrine chromium cells.
in the normal development process, the malignant state also summarizes the proliferation/differentiation of chromium-phil cells.
findings of the study provide insights into the trajectory and cellular state of NB's human start-up and development.
In summary, the study's single-cell data sets and analyses will be useful resources and provide a reference for future studies to decode spontaneous NB degeneration of cellular and molecular mechanisms and the critical intercellular crosstalk needed to maintain cellular state under developmental and disease conditions.
concept has been put forward that malignant tumors in children are most likely caused by prescellular cells during embryonic development or early post-birth development.
advances in single-celled studies have strengthened the link between tumor occurrence in several childhood cancers and abnormal development of associated fetal cells.
neuroblastoma (NB) from the original cells of the sensory nervous system and is the most common extracranial solid tumor in childhood.
neuroblastoma is thought to originate in the back aortic stem nerve crest cells (NCC), also known as intersecting adrenal progenitor cells, which are premeditates to the sensory neurons and neuroendocrine (NE) chrome cells.
, however, genetic linee tracking results challenge this hypothesis, suggesting that two waves of NCC migration led to the development of an emotional adrenal linee.
NB tumor cells can also carry identified epinephrine and undifferentiated NCC-like esophageals.
suggests that NB tumors may occur earlier than the migration phase before the NCC moves into the adrenal fate of the intersection.
despite these studies, there is still a lack of understanding of the diversity of NB esolytes at single-cell resolution.
therefore, the study aims to clarify the espics of NB tumor cells by linking their esopes to assumed origins through the use of single-cell transcription analysis.
the wide distribution of NB, the study focused on adrenal NB, which accounts for about 47 percent of NB.
study sequenced single-cell RNA (scRNA-seq) of early human embryos and fetal adrenal and primary adrenal NB tumors.
, the study used this unique resource to identify transcriptional characteristics of NB tumor cells and esotype diversity associated with clinical heterogeneity. The
-article pattern map (pictured from Canser Cell) using single-cell RNA sequencing produced adrenal NB transcription groups from 160,910 cells in 16 patients and a transcription group of presumed developmental cells of NB origin from 12,103 cells in early human embryos and fetal adrenal glands at a relatively early stage of development.
study found that most adrenal NB tumor cells transprine mirror-imaged epinephrine chromium cells.
in the normal development process, the malignant state also summarizes the proliferation/differentiation of chromium-phil cells.
findings of the study provide insights into the trajectory and cellular state of NB's human start-up and development.
In summary, the study's single-cell data sets and analyses will be useful resources and provide a reference for future studies to decode spontaneous NB degeneration of cellular and molecular mechanisms and the critical intercellular crosstalk needed to maintain cellular state under developmental and disease conditions.
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