Cancer cell: cancer will happen if you die! Dead cancer cells make living glioma cells more resistant

June 25, 2018 / BIOON / - Highlight of this study: apoptotic extracellular vesicle Apievs can promote the generation of glioblastoma (GBM), which is more malignant and more resistant to treatment Apievs is rich in splicing protein and snrnas Apievs can affect the mRNA splicing of GBM cells Rbm11 is part of the reason for the malignant changes of GBM cells mediated by apoevs Photo source: in Dr triche National Cancer Institute's malignant tumors like GBM, there are many apoptotic cells around the tumor cells that keep proliferating, but the researchers have not paid attention to the signal communication between these apoptotic cells and living cells before In a recent study published in cancer cell, researchers from the University of Alabama, Birmingham, found that apoptotic GBM cells can promote the sustained proliferation of living GBM cells by secreting apoevs rich in different splicing components, and improve their ability to tolerate treatment Apoevs can change the RNA splicing of GBM cells, so it can promote these cells to be more resistant, more malignant, and easier to migrate Through the mechanism study, the researchers found that rbm11 is a representative splicing factor significantly up-regulated after tumor treatment Once tumor cells apoptosis, it will be enriched in apoevs Once these apoevs are phagocytized by the receptor GBM cells, these exogenous rbm11 will change the splicing state of MDM4 and cyclin D1, making them express more carcinogenic proteins, so that these GBM cells are more resistant to treatment and more malignant In general, this study found that apoptotic GBM cells also play their "residual heat", helping the remaining GBM cells to avoid the killing of the treatment Inhibition of these apoevs may be a new way to prevent drug resistance and tumor recurrence Reference materials: Ichiro Nakano et al Apoptotic cell derived extractive practices promote malignancy of glioblastoma via intercellular transfer of spreading factors, "cancer cell (2018) Doi: 10.1016/j.ccell.2018.05.012