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YAP protein (Yes-Associated Protein), the core effector of the Hippo signaling pathway, is a multifunctional intracellular connexin and transcription co-activator, which plays a role in signal transduction and gene transcription regulation in normal cells
YAP protein YAP protein
July 2021,Hill Hospital, researchers at the University of Toronto in the journal Cancer Cell published a report entitled: Binary PAN-Cancer classes with DISTINCT Vulnerabilities defined by Pro- or Anti-Cancer YAP / Activity TEAD research papers
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity
The study shows that all cancers can be divided into two categories based on whether they express YAP protein.
As an important regulator and effector of the Hippo signaling pathway, YAP plays an important role in the formation of malignant tumors.
When culturing cancer cells in the laboratory, the cancer cells are either suspended or adherent, and YAP is its main regulator.
In cancer cells, the closing or opening of YAP has the opposite effect of promoting or suppressing cancer.
The research team also found that YAPoff cancers are usually highly lethal , such as retinoblastoma, small cell lung cancer, and neuroendocrine prostate cancer
YAPoff cancer is usually highly fatal
Some cancers such as prostate cancer and lung cancer can also transition from YAPon state to YAPoff state to resist treatment
In general, this study shows that all cancers can be divided into two categories based on the presence or absence of YAP protein-YAPon cancer and YAPoff cancer
According to the presence or absence of YAP protein, all cancers can be divided into two categories-YAPon cancer and YAPoff cancer
Original source:
Original source:Joel D.
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