Cancer: Can oral bacteria increase the risk of esophageal cancer?

Esophageal cancer is one of the most common gastroesophageal malignancies.
according to the 2018 Global Cancer Statistics Report, there were about 570,000 new cases of esophageal cancer and about 500,000 deaths worldwide in 2018, ranking 7th in malignant tumor incidence and 6th in death.
because of China's large population base, 50% of the world's esophageal cancer is concentrated in China, and the incidence rate of men is higher than that of women.
Due to the aggressiveness of esophageal cancer, the early diagnosis is difficult, and the two main subtypes of esophageal cancer, squamous cell carcinoma and adenocarcinoma, have different risk factors, manifestations and morbidity in different populations, and are usually late after diagnosis.
, a better understanding of the risk factors for esophageal cancer can help with early diagnosis and treatment.
, researchers from Tokyo Medical and Dental University published a study in the journal Canesr that showed that oral bacteria are involved in the development of stomach and esophageal cancers.
In the study, researchers collected plaque and saliva samples from 61 patients with esophageal cancer and 62 healthy controls, using real-time polymerase chain reaction techniques to assess the abundance of common oral bacterial periodontogenic pathogens, including lysozyme, Kercobacteria, gum pyridobacteria, intermediate Prevo bacteria, Forsythtana bacteria, fouling helix and streptococcus.
found that cancer patients who smoked and drank alcohol had poorer gum health.
, the abundance of line bacteria and streptococcus was significantly higher in patients with esophageal cancer than in the control group.
in the removed cancer tissue, the detection rate of streptococcus pharyngitis was 67.6%, the detection rate of 94.6% of the nucleobacterium difficile, and the detection rate of other bacteria was less than 40%.
In order to assess the risk factors of esophageal cancer, single-variable logic analysis and multi-logical regression analysis were carried out in the analysis of oral bacteria in dental plaque, saliva and mucus, and the OR value of fossestania was higher.
the model based on Bayes's information standard method, drinking habits, streptococcus pharyngitis in dental plaque, Fossestana bacteria, and cocooning line bacillus in saliva all had higher OR values.
, the study revealed a positive correlation between esophageal cancer and plaque and specific oral bacteria, and alcohol consumption was associated with a risk of esophageal cancer.
, it shows the diagnostic potential of oral bacteria in esophageal cancer and lays the foundation for further screening methods.