Cancer: Anti-cancer "new weapon"! Vitamin D could provide a 'protective umbrella' for the hottest cancer treatments

Cancerimmunotherapytherapy has been hailed as the third revolution in cancer treatmentAs the hottest form of cancer treatment, it does not rely on drugs to kill cancer cells, but on the human body's own immune system to act on cancer cellsHowever, while this approach has helped many patients extend their lives, they can still "mistakenly hurt" normal human tissues and cause diseases, including colitisJune 22nd, a study published by cancer, a peer-reviewed journal of the American Cancer Society (ACS), (
Influence Factor: 5.238) put a "safety lock" on cancer immunotherapya team of researchers at Harvard Medical School found that takingvitamin Dsupplements may helpprevent potentially serious side effects ofcancer immunotherapyThis is also the first study to identify vitamin D as a protective factor to prevent colitis caused by immunotherapy"Cancer immunotherapy-induced colitis limits the use of this life-saving method, leading to the termination of treatment," said Osama Rahma, M.D., of the Dana-Farber Cancer Institute at Harvard Medical SchoolAlthough colitis is one of the most common and serious adverse reactions to cancer immunotherapy, little is known about the options that can be used to prevent this side effect 2008, a study published in Nature Clinical Practice Rheumatology suggested that vitamin D may affect the immune system in the case of autoimmune diseases and inflammatory bowel disease To test whether vitamin D has the potential to reduce the risk of colitis from immunotherapy, Rahma and colleagues launched the study between 2011 and 2017, 213 melanoma patients received at least one course of treatment of pembrolizumab, nivolumab, ipilimumab or the combined use of ipilimum and nivolumab (immune test ingon inhibitors) Of these, 66 patients took vitamin D supplements before treatment In the end, 37 patients were pathologically confirmed to have colitis Study on the incidence of colitis based on immunocheckpoint inhibitors multivariate regression showed a 65 percent lower risk of colitis in patients taking vitamin D This finding was validated in subsequent studies Of the 169 melanoma patients treated at Massachusetts General Hospital, 49 had colitis, and those who took vitamin D had a 54 percent lower risk of developing colitis Logistic regression analysis of the multivariate logistic regression analysis of colitis risk factors not only prevents side effects of cancer immunotherapy, vitamin D also helps patients with cancer prevention In an opinion piece published on May 30th in the journal Seminars in Cancer Biology, researchers at the University of Eastern Finland and the Autonomous University of Madrid suggest edited that good vitamin D status is good for cancer prevention and prognosis for some cancers The anti-cancer effect sonofing effect of vitamin D is particularly evident in the prevention and treatment of colon cancer and blood cancer in In addition, the high reactivity of vitamin D may be associated with a lower risk of cancer, although this response varies from person to person in short, the new study suggests that taking vitamin D before starting cancer immunotherapy will help patients fight the side effects that come with it Larger-scale prospective studies are needed to verify whether vitamin D supplementation is a safe, accessible and cost-effective way to prevent the toxicity of immunotherapy to the gastrointestinal tract and to increase the effectiveness of immunocheckpoint inhibitor treatment in cancer patients