Can vaccination be immune for life? Study finds vaccine persistence linked to genetics

Recently, something has been shocked to the small editor! Xiao xiao went to the hospital to do a normal can no longer ordinary physical examination, after the medical report to the doctor for ten seconds, the doctor has been silentI was in a flash and was in a mess, and my brain was filling in all kinds of bad newsresults, looking at my head full of cold sweat, the doctor silently said: "Your hepatitis B vaccine has almost no antibodies, ready to hit the enhancer bar!" "What?!!! What is an enhancer? Isn't the vaccine effective for a single injection?to make up for the knowledge blind spot, the editor began looking for information to supplement the relevant knowledge, and found a recent paper published in the journal Cell Reports on the persistence of vaccine-induced immunityIt turns out that vaccine persistence is also genetically relatedhttps://doi.org/10.1016/j.celrep.2019.05.053vaccine-induced immunity persistence is concernedmaintaining antibody levels in the blood that are sure to work, is one of the important conditions to prove the continuity of the vaccineHowever, each person's physique is different, the vaccine in the body's antibody level changes are quite different, for example, like small, in infancy after injection of some vaccines, along with the growth of antibody levels gradually decreased, the need for enhancers to supplement the vaccine's antibody levelsDr Daniel O'Connor, lead author of thelatest paper and a researcher in the department of pediatrics at the University of Oxford, said: "The emergence of strong and persistent vaccine-induced immunity from birth is an important part of global health action to combat the burden of infectious diseasesHowever, in today's vaccine-wide, it is important to understand the mechanisms of the persistence of antibodies, as the effectiveness and acceptability of vaccines increase and infants continue to be protected after immunization, eliminating the need for repeated reinforcement of protection throughout childhoodGWAS explores the "secrets" of immune persistence
However, vaccine response and immunity persistence are determined by a variety of factors, such as age, gender, race, microbiome, nutritional status, and infectious diseasesTwin studies have also shown that vaccine-induced immunity is highly hereditaryRecent research has begun to explain the genetic componentbehind this complex traitIn the latest study, researchers conducted a genome-wide association analysis (GWAS) on 3,602 children in the UK and the Netherlands They focused on three conventional childhood vaccines: meningococcal C,meningococcal (MenC), Haemophilus influenzae type b and tetanus toxin (TT), which can prevent life-threatening bacterial infections They analyzed about 6.7 million affecting unit DNA mutations, single nucleotide polymorphisms (SNPs) associated with vaccine-induced blood antibody levels https://doi.org/10.1016/j.celrep.2019.05.053 finally, the researchers identified two sites associated with the continuity of immunity induced after vaccination in children the persistence of MenC immunity is associated with SNPs in the genomic region containing a range of signal-regulating proteins that are involved in immune signaling At the same time, the persistence of TT-specific immunity is associated with SNPs in human leukocyte antigen (HLA) gene sites The HLA molecule provides peptides to T cells, which induce S-cells to produce antibodies Of course, the researchers also found that these mutations may be just the tip of the iceberg behind the "genetic" determinants behind vaccine-induced immune persistence In addition, they are not sure whether the findings apply to ethnic groups other than Caucasians in britain and the Netherlands But the authors say neonatal screening methods may soon incorporate genetic risk factors for predicting immune persistence, paving the way for personalized vaccine programs future, researchers plan to conduct further research in larger children and other people who benefit from vaccination to explore how genetic makeup affects vaccine response references: s1 s- Common Genetics Associates with the severifs of Immunity to the child Ofme Sing Immunization The persistence of the newly discovered vaccine may be genetically related