Can probiotics prevent Alzheimer's disease?

Alzheimer's disease mostly occurs in the pre-age and old age, and the occurrence after 65 years of age is called Alzheimer's disease (Alzheimer's disease, AD)

Some people say that Alzheimer's disease is God's most vicious curse

Recent clinical studies have shown that 20 years before the appearance of clinical symptoms of AD, pathological changes characterized by β-amyloid (Aβ) plaques and tau protein fibrillary tangles appeared

More and more studies have shown that the intestinal flora is one of the key factors regulating intestinal brain function

Recently, the team of Takuji Yamada of Tokyo Institute of Technology in Japan published a research paper titled "Identification of prausnitzii Faecalibacterium strains for intestinal microflora intervention in Alzheimer's dementia" in "Cell Reports Medicine"

research content

First, in order to identify potential microbial populations to prevent MCI, the authors conducted a cross-sectional study

The results showed that there was a difference in the microbial genus composition between the healthy group and the MCI group (R2 = 0.

Among 129 genera, the differential abundance analysis of ALDEx2 showed that there were significant differences in the abundance of 6 genera between the healthy group and the MCI group

In addition, the authors found that the abundance of prausnitzii Faecalibacterium had the most significant correlation with MCI disease, and the abundance of this strain in the MCI group was significantly reduced

On the basis of comparative analysis of the composition of intestinal microbes, the authors further screened and isolated the Plaueus F.

In order to test the causal relationship between Plaunitz F.

A β-injected mice were given oral treatment with Fp14 and Fp360.

After confirming that Fp14 and Fp360 are effective strains, through whole-genome comparison and metagenomic shotgun sequencing, the specific homology found only in these effective strains was confirmed, and the healthy group was more abundant than the MCI group

Since one of the limitations of Platts F.

Metabolome analysis detected 355 metabolites

RNA-seq analysis also detected 15 differentially expressed transcripts

 Original title:

Identification of Faecalibacterium prausnitzii strains for gut microbiome-based intervention in Alzheimer's disease-type dementia