Can natural product pesticides achieve artificially high yields?

Recently, the green target molecule design and innovation team of the Institute of Plant Protection of the Chinese Academy of Agricultural Sciences was invited by the "Current Opinion in Biotechnology" to systematically elaborate on the transformation of the metabolic pathways of the natural product pesticide precursors of Streptomyces polyketones and the high-yield strains.
Synthetic biology strategy
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This review has broad guiding significance for the use of synthetic biology strategies to reconstruct more efficient natural product pesticide synthesis pathways and obtain high-yield industrial production bacteria
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According to associate researcher Li Shanshan, natural product pesticides have the characteristics of high efficiency, safety, and good environmental compatibility, and they have an indispensable strategic position in the prevention and control of plant diseases and insect pests and the protection of China's food security
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Streptomyces is an important industrial strain for the production of natural pesticides
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However, the growth and metabolism regulation mechanism of Streptomyces is complicated, and the development of high-yielding bacteria is slow.
The fermentation industry faces common problems such as low yield and high cost, which seriously hinder the development and application of natural product pesticides
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The high yield of the target natural product and the growth of the strain are inseparable from the precursor pathway
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Therefore, constructing an efficient precursor supply pathway is of great value for the healthy growth of strains and increasing the yield of target natural products
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This article systematically described the biosynthetic pathways of Coenzyme A precursor substances necessary for the biosynthesis of the polyketide natural products of Streptomyces, including self pathways and heterologous pathways; at the same time, it also summarizes the optimization and adaptation of these in the process of increasing the yield of strains.
Synthetic biology strategies for metabolic pathways
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It is understood that the research was funded by the National Natural Science Foundation of China and the Science and Technology Innovation Project of the Chinese Academy of Agricultural Sciences
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(Unit: Institute of Plant Protection, Chinese Academy of Agricultural Sciences) Editor: Yao Zhaohui [Source: Guangming Net]