Can cancer and AIDS be cured? The essence of Tencent ME conference is in these twenty thousand words.

We always try our best to fight against disease We always pick up the most cutting-edge technology and tools of each era to explore the secrets of disease and play games with it On November 4, an in-depth discussion on life and disease began in Beijing, which is about to enter the winter Six years ago, Tencent invited dozens of rare scientists from all over the world to Beijing exhibition hall to hold the first we conference There is no business or competition here People only discuss the most cutting-edge science and ideas and only care about the future of mankind Six years later, the first Tencent medical me conference, jointly built by Tencent and its Tencent medical code, together with NEJM medical frontier (a journal of NEJM group, the world's top general practice Journal New England Medical Journal), also opened a new journey in Beijing exhibition hall Six of the world's top medical scientists and clinicians gathered together to focus on cancer, depression, AIDS, geriatric diseases and other topics of most concern in China, and share the world's leading medical breakthroughs For this conference, Ma Huateng, chairman and CEO of Tencent's board of directors, hopes to "guide more people to pay attention to life, understand themselves, improve public health through authoritative medical science popularization, and reduce the suffering of illness." In May this year, a circle of friends of Ma Huateng revealed for the first time that "technology for the better" will become Tencent's new vision and mission Through the power of science and technology, to enhance the public's attention to life and health is also Tencent's "science and technology for the good" initiative In this information age, the Internet has become an important channel for people to obtain medical information However, due to the influence of disguised advertisements and lack of authoritative sources, the lack of various medical information and mistakes are common, and the public's tolerance for such "popular science content" which is not rigorous and authoritative has reached the limit At the same time, the public is often confused by rumors and lacks basic doubts and torture about some so-called medical common sense Therefore, in addition to knowledge, we need a rational and scientific way of thinking to make better medical judgment and choice In 2017, Tencent established a professional science platform "Tencent medical code" Here, more than 3000 medical experts are communicating more scientific and understandable medical knowledge to the public In a congratulatory letter to Tencent medical me conference, Tu Youyou, China's first Nobel Prize winner in physiology or medicine, wrote that: medical workers should not only pick up the scalpel, but also take up the pen, help people's health with the scientific spirit of professional truth-seeking and rational, and improve the common destiny of mankind together The 6 experts invited by the conference, each of whom is an important figure in the medical field, are practicing the spirit of holding both the scalpel and the pen pole: Zhu xiuxuan, director of hepatoma research, Massachusetts General Hospital, and lifelong professor of Harvard Medical School, is an internationally recognized authoritative expert on HCC and cholangiocarcinoma Li Taisheng, director of infection department of Peking Union Medical College Hospital of Chinese Academy of Medical Sciences and double professor of Tsinghua University School of medicine, established "cocktail therapy" for Chinese AIDS patients, presided over the development of China's first "AIDS diagnosis and treatment guide", and established the basic norms for doctors to diagnose and treat AIDS in China Fei Lipeng, consultant of the mental health department of the World Health Organization and professor of clinical psychiatry and clinical epidemiology of Columbia University in the United States, led the establishment of China's first medical institution for suicide groups, and established the first (and largest) National 24-hour psychological crisis hotline Xiao Ruiping, director of the Institute of molecular medicine of Peking University, Professor of lifelong lecturer and deputy editor in chief of New England Journal of Medicine (NEJM), has opened a new way for pathophysiology and clinical treatment of heart failure Tibor Kovacs, senior honorary lecturer of King's College London and President of European Society of oncology, is a leading figure in the field of international breast cancer research David P Ryan, clinical director of the cancer center of Massachusetts General Hospital and lifelong professor of Harvard Medical School, has more than 20 years of clinical experience in the field of cancer treatment In addition, renowned debater Qiu Chen and Tencent medical vice president Zhang Meng also shared medical related content from the perspective of users and industry Before the beginning of the meeting, some speakers had accepted interviews with media including eight health news We tried to compile the essence of all the 8 speakers' speeches and the contents of interviews, so that readers could read their insights into the cause of human health in an article It's a long article, but it's worth your time reading it Zhu xiuxuan is an internationally recognized authoritative expert in HCC and cholangiocarcinoma He focuses on two aspects of cancer, from principle, new treatment methods to systematic research of new drugs Through the exploration of new treatment methods such as molecular targeted drug research, targeted drug combined with chemotherapy, immunotherapy and proton radiotherapy in primary liver cancer, he treats advanced HCC and cholangiocarcinoma Significant impact His breakthrough research also pushed the FDA to approve two new drugs for clinical treatment of advanced liver cancer, bringing new vitality to patients around the world △ Zhu xiuxuan, director of hepatoma research, Massachusetts General Hospital, lifelong Professor, Harvard Medical School On Christmas Eve last year, a 66 year old male patient was transferred from Florida to Boston (a straight line distance of about 1900 kilometers) to the Massachusetts General Hospital Clinic where I worked He has had abdominal distention for several months with severe weight loss From the results of the physical examination, we can see that he is very thin, and the swollen liver area can be seen in the distance On CT, we saw a huge mass on the left side of him with abdominal lymph node metastasis, which was quickly confirmed as a primary liver cancer by liver biopsy At that time, we happened to have a clinical trial to study the application of the combination of PD-1 inhibitor paimmumab (keytruda, K drug) and lovatinib in the treatment of advanced liver cancer The patient was very happy to join in Four months after the start of treatment, his mass basically disappeared, and alpha fetoprotein also decreased from more than 60000 before treatment to the normal value Now the patient has received the same treatment for 10 months, and all disease-related symptoms have completely disappeared Liver is a very important organ of human body, which has a rich supply of blood vessels Because of this, liver is one of the most common tumor metastasis organs Today I want to share with you the primary malignant tumor of the liver 80% - 85% of the primary malignant tumors of the liver are HCC, commonly known as liver cancer In addition, 10% - 15% of them are intrahepatic cholangiocarcinoma, and there are some relatively rare primary intrahepatic tumors Worldwide, the incidence rate of liver cancer ranks sixth, and mortality rate is fourth Worldwide, 55% of liver cancer occurs in China, but in recent years the incidence rate in the United States and Europe has also been rising Many people in China talk about cancer discoloration, and they may be more afraid of liver cancer According to the latest report, liver cancer, stroke, ischemic heart disease, lung cancer and chronic obstructive pulmonary disease have become the five major causes of death in China Can liver cancer be prevented? In fact, liver cancer has many very mature pathogenic factors, such as hepatitis B, hepatitis C, excessive alcohol intake, and fatty liver We have a good way to block each cause For example, in China, hepatitis B has a very high incidence rate through mother to child transmission and other means We can effectively block hepatitis B virus through vaccine and control of hepatitis B virus infection Although we don't have a vaccine for hepatitis C, we have a very high cure rate Controlling alcohol intake and improving life style are also effective ways to control liver cancer The treatment of liver cancer is completely based on the stage of the disease The oncologist will make some specific evaluation and determine the treatment method according to the patient's tumor load, all the specific conditions of liver function and physical condition Early liver cancer we can consider ablation; multiple liver cancer we can consider interventional therapy; if liver cancer has systemic metastasis, systemic systemic therapy is our main treatment Can liver cancer be cured? I'm here to make it clear to you: the cure rate of early diagnosed liver cancer is very high, which can be treated by surgical resection, liver transplantation and radiofrequency ablation, which are very good treatment methods for early liver cancer How can it be cured? Early screening is very important At present, the conventional methods include the determination of alpha fetoprotein, the application of liver ultrasound, and we are trying to develop some circulating, more sensitive and specific early diagnosis methods in the laboratory If there are multiple liver lesions, we also have some other very effective local treatment, including chemical interventional therapy and radiation interventional therapy Once the tumor has metastasis, the main treatment depends on systemic therapy By 2019, we have 5 targeted drugs, 2 PD-1 antibodies, all of which have been approved by FDA in the United States The treatment of liver cancer has changed from traditional chemotherapy to target therapy, and now it is turning to immunotherapy At the same time, we are trying to explore how to further improve the cure level of liver cancer through combined treatment Today, we have evidence that effective and systematic chemotherapy, targeted drugs and immunotherapy can gradually prolong the total survival time of patients Although in targeted therapy, we rely on many gene detection techniques to show us whether there are specific targets that can be attacked However, in the treatment of liver cancer, the main application is the understanding of tumor microcirculation, that is, how to block tumor angiogenesis, how to use their own immune cells to attack the tumor in vivo We are carrying out further exploration in the field of liver cancer treatment, and how to use combination drugs reasonably At present, we have been able to combine immunity with immunosuppressive agents, such as the combination of nivolumab (opdivo) and yervoy (CTLA4 inhibitor), which has been able to make patients with advanced liver cancer live for 22 months The third phase of clinical trials is starting, and we are looking forward to this result In addition, we are using a combination of antiangiogenic inhibitors and targeted checkpoint inhibitors, such as PDL1 inhibitors atzumab and bevacizumab In the combined use of these two antibodies, the first phase of clinical trial results reached 36% of the tumor remission rate, of which 12% could be completely relieved, which has never been seen in the history of drugs and liver cancer Both arizul and bevacizumab have reached the effective standard in terms of overall survival period and progression free life period We will officially announce their results later this month Therefore, this combination therapy has now become the standard treatment plan for advanced liver cancer treatment, and I also look forward to more good plans The combination of lovatinib and pamumab also achieved 46% of the tumor remission rate in the late stage of liver cancer Because of this, FDA has recognized this combination scheme as an accelerated development, and the third phase of the experiment is further carried out Cholangiocarcinoma is a very heterogeneous tumor, which includes intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, gallbladder cancer, and the biological course of these tumors