Brit J Cancer: Relationship between female exogenous hormones and reproductive factors and risk of biliary cancer in the liver

Hepatic biliary tube cancer (ICC) originates from bile duct cells in the liver's biliary tube and is the second most common type of liver cancerBile duct cells express both estrogen alpha and beta receptors, while estrogen regulates the proliferation of bile duct cells positivelyStudies involving men and women have shown that elevated levels of circulating estradiol are associated with increased ICC risk and further support for hormone etiologyHowever, no observational studies have assessed the association between exogenous hormones and reproductive factors, such as endogenous hormone levels, and ICC riskrecently published a research paper in British Journal of Cancer, an authoritative journal on the field of oncology, who collected data from 1107,498 women in the North American-based cohort study (the liver cancer merger project, LCPP) and the UK biobank between 1980 and 1998 and from 2006 to 2010, respectively, and used the Cox Proportional Regression Risk Regression Model to obtain risk ratio (risk ratio) (CI) and 95% confidence interval (CI)The estimates of LCPP (n-180 cases) and the UK biobank (n-57 cases) are then combined using meta-analysisdoubled the risk of EC C in hysterectomy women compared to women aged 50-54 years (HR ?1.98, 95% CI 1.27-3.09)Long-term oral contraceptives (more than 9 years) were associated with a 62% increase in ICC risk (HR 1.62, 95% CI 1.03-2.55)There is no association between ICC risk and other external hormone use or reproductive factorssuggests that the results suggest that hysterectomy and long-term oral contraceptives may be associated with an increased risk of ICC