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A new study of genetic data from more than 400,000 UK adults, published Wednesday 20 April, has revealed a clear link between walking speed and genetic markers of biological age
Confirming a causal relationship between walking speed and leukocyte telomere length (LTL) -- an indicator of biological age -- based on Leicester's team's estimates that a lifetime of brisk walking can make a person's reduce the biological age by 16 years
Researchers from the Leicester Biomedical Research Centre at the University of Leicester's National Institute of Health Research looked at genetic data from 405,981 middle-aged UK Biobank participants and found that faster walking speed independent of physical activity was associated with longer walking speed.
Telomeres are the "caps" at the end of each chromosome, and they contain repetitive, noncoding DNA sequences that protect the chromosome from damage, much like the caps at the ends of shoelaces prevent shoelaces from unraveling
Each time a cell divides, these telomeres shorten until they are so short that the cell can no longer divide, a process known as "replicative senescence
Although the relationship between telomere length and disease is not fully understood, the formation of these senescent cells is thought to be involved in a range of aging-related symptoms, such as frailty and age-related diseases
While the physical, mental, social, and health benefits of walking are well documented, this study is the first of its kind to correlate genetic data with participants' self-reported walking speeds and wearable activity tracking worn by participants.
Dr Paddy Dempsey is a Lecturer and Research Fellow at the University of Leicester and at the University of Leicester's Leicester Biomedical Research Centre (part of the Leicester University Hospitals NHS Trust) and is also part of the research published in Communications Biology the lead author
"This study uses genetic data to provide stronger evidence for a causal relationship between faster walking speed and longer telomere length.
"This suggests that measures such as getting used to slower walking speeds are an easy way to identify people at greater risk for chronic disease or unhealthy aging, and that activity intensity may play an important role in optimizing interventions
Researchers from the University of Leicester have previously used the UK Biobank to show that just 10 minutes of brisk walking a day can increase life expectancy, with fast walkers living 20 years longer than slow walkers
The new study demonstrates a causal relationship between brisk walking and telomere length, importantly, not the other way around
Tom Yates, senior author and professor of physical activity, sedentary behaviour and health at the University of Leicester and NIH's Leicester Biomedical Research Centre, added: "While we have previously shown that walking speed is a health condition A strong predictor, but we haven't been able to say for sure that brisk walking speed actually leads to better health
"UK Biobank cohort survey reveals causal relationship between self-reported walking speed and telomere length," published in the journal Communications Biology
Provided by University of Leicester
