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When cancer cells break away from the primary tumor and metastasize to other organs, it's called "metastatic cancer
Starting at the primary site of a tumor, cancer cells can invade their microenvironment and then circulate through the blood and lymphatic vessels to distant healthy tissue, forming metastases
plasticity of tumor cells
Although the molecular and cellular mechanisms underlying the different stages of the metastatic process are not fully understood, studies suggest that cellular plasticity plays an important role
The laboratory of Prof.
"Unlike women, mice transplanted with human breast cancer cells metastasized to the lungs, not the bones," said Nastaran Mohammadi, lead author of the study and a researcher in the Division of Molecular and Cellular Biology.
guided bone transfer
In in vitro migration and invasion experiments, the scientists found that ZEB1-expressing cancer cells metastasized to bone tissue, unlike cancer cells that did not express ZEB1
"We can therefore hypothesize that this factor is expressed during tumor formation and directs cells that have acquired metastatic characteristics to metastasize to the bone," explains Didier Picard, corresponding author of the study
This study confirms the importance of tumor cell plasticity in the metastatic process, and in the long term, new treatments can be considered to prevent the emergence of metastases
Provided by the University of Geneva
