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BREAST CANCER RES TR: Can low-risk early breast cancer be treated without chemotherapy after surgery?

 Last Update: 2021-10-19
 Source: Internet
 Author: User

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breast cancer receptors

hepatocyte growth factor

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Human epidermal growth factor receptor (HER2-positive) breast cancer accounts for about one-fifth of all breast cancers

Breast Cancer In the APT study, weekly paclitaxel + trastuzumab treatment of HER2 positive + tumor ≤ 3 cm + invisible lymph node patients, the 7-year disease-free survival rate was 93%

The purpose of this study was to compare trastuzumab ± chemotherapy after surgery for HER2-positive early breast cancer with tumors ≤ 2 cm and negative lymph nodes

In the National Cancer Database (2004-2017), patients with a preliminary diagnosis of pT1N0M0 HER2-positive breast cancer were divided into two groups: (i) anti-HER2 monotherapy, namely trastuzumab, (ii) chemotherapy-trastuzumab Combination therapy with benzumab

A total of 23281 patients met the criteria

After matching, compared with trastuzumab monotherapy, patients with chemotherapy-trastuzumab combination therapy have a moderate survival advantage (5-year OS 94.

Therefore, the results of this big data review study show that for patients with HER2-positive early breast cancer with tumors ≤ 2 cm and negative lymph nodes, although trastuzumab combined with chemotherapy is compared with trastuzumab monotherapy, 5 years The overall survival rate is 3.

Original source:

Cao L, et al.

Breast Cancer Res Treat.

DOI: 10.

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