Breakthrough of component Chinese medicine innovation?

At present, the medical interface is facing a huge challenge brought by the change of disease spectrum The multifactor complex diseases represented by tumors, cardiovascular and cerebrovascular diseases, metabolic diseases and geriatric diseases have become the mainstream, which makes the research and development of compound drugs become the main direction of new drug research and development As a result, more and more attention has been paid to the traditional Chinese medicine with compound prescription and comprehensive prescription How to use the traditional Chinese medicine with thousands of years of clinical practice to develop new drugs and how to use this opportunity to complete the innovation of traditional Chinese medicine has become an important topic in the field of traditional Chinese medicine In this context, the 418th Xiangshan scientific conference takes "component traditional Chinese medicine" as the theme, hoping to gather the wisdom of all parties and find a breakthrough for the innovation and modernization of traditional Chinese medicine Zhang Boli, one of the executive chairman of the meeting and President of the Chinese Academy of traditional Chinese medicine, said: "it is a key task for the development of traditional Chinese medicine industry to analyze the 'drug information' contained in traditional Chinese medicine compound, and component traditional Chinese medicine is one of the ways to innovate the research of traditional Chinese medicine." As a bridge between the theory of medicine and clinical practice, prescriptions embody the characteristics of traditional Chinese medicine in treating diseases Traditional prescriptions are mostly made of pieces of decoction, which are complicated in composition, hard to control in quality and hard to explain in therapeutic mechanism The human body of prescriptions is also a complex system In the face of double complex systems, it is necessary to conduct dimension reduction research under the guidance of complexity science theory Academician Wang Yongyan, honorary president of the Chinese Academy of traditional Chinese medicine, believes that we must learn from the research methods of modern pharmacy, give full play to the theoretical advantages of traditional Chinese medicine, maintain the compatibility characteristics of traditional Chinese medicine prescriptions, develop and innovate traditional Chinese medicine, and explore the Scientific Mysteries of the complex system of prescriptions at the same time According to the introduction, component Chinese medicine is a modern Chinese medicine based on the theory of traditional Chinese medicine, following the theory and principle of formula compatibility, absorbing modern drug development methods and technologies, and made up of effective components or effective parts, which is a way to innovate the research of traditional Chinese medicine In 1999, the scientific research team with Wang Yongyan and Zhang Boli as the chief scientists developed the research of modern Chinese medicine with "component compatibility" in the first 973 Plan of Chinese medicine industry Up to now, the third 973 Plan of component Chinese medicine has been progressing smoothly, and the R & D mode and technical system of component Chinese medicine have been formed, and the technical route of "standard component, component effect relationship, component compatibility and optimal design" has been established According to Zhang Boli, the characteristics of component traditional Chinese medicine are "two basic clearness": the material basis and mechanism of action are relatively clear; the quality is stable and controllable, and the evidence of safety and effectiveness is sufficient The mode of action of component traditional Chinese medicine is multi-channel, multi-target and multi effect integrated regulation, which not only keeps the advantages of compatibility of traditional Chinese medicine, but also improves the quality control level and clinical efficacy of traditional Chinese medicine preparations Wang Yongyan pointed out that the traditional prescription of traditional Chinese medicine is to regulate the balance of yin and Yang of human body according to the principle of "correspondence between heaven and man", reflecting the overall regulation of drug interaction to achieve the balance of effectiveness and safety Although material separation and analysis technology has been greatly developed, and various kinds of histochemical resources are constantly enriched and integrated, it is still not enough to fully explain the complex relationship between effective substances and mechanism of action Components of traditional Chinese medicine can not completely represent decoction pieces He believes that the core of the current research and development of component Chinese medicine is to balance the relationship between efficacy and toxicity, and seek the maximum possible efficiency and toxicity reduction That is to say, the possible toxicity brought by the convergence of component Chinese medicine to compounds and the potential efficacy substances contained in discarded components cannot be ignored, so as to maintain and improve the efficacy of component Chinese medicine distribution without increasing The risk of drug addition is one of the important topics in the study of components Experts at the meeting believed that the current technical path of research and development of component Chinese medicine should start from the classical formula and large varieties, that is, the secondary development of modern Chinese medicine with clear target and objective evaluation of effect and small compound Chinese medicine with exact effect According to the introduction, at present, the systematic development of large varieties of modern Chinese medicine has achieved gratifying results For example, in 2011, the number of large varieties of traditional Chinese medicine sold by more than 100 million in Tianjin increased from 2 to 10 The total annual sales of 30 varieties of traditional Chinese medicine reached 3.15 billion yuan, more than 2.5 times higher than that in 2006 It is one of the executive chairman of the great challenge meeting to clarify the mechanism of the important prescriptions Yao Xinsheng, academician of the school of medicine of Jinan University, thinks that the traditional Chinese medicine, which is used in many departments, is composed according to certain rules under the guidance of the theory of traditional Chinese Medicine, and pays attention to the monarch and his subjects' assistance and dialectical treatment The different compatibility of components not only has different action intensity, but also has qualitative change Therefore, the efficacy of the prescription can not be simply regarded as a simple addition of several single Chinese medicine At present, the number of prescriptions is about 60000, about 10 times the number of traditional Chinese medicine Therefore, it is more important and more difficult to clarify the material basis and mechanism of TCM prescription, but it should be the main content of TCM innovation research He believes that the normal and healthy human body has extremely complex self-regulation system, which can be compared to a dark box The same is true of traditional Chinese medicine prescriptions It is a very complex task to link the two complex systems and to fully elucidate the regulatory effect of traditional Chinese medicine on the overall function of human body and its corresponding material basis Only on the basis of thousands of years of clinical experience of TCM and the guidance of TCM Prescription Theory, using modern scientific methods to reveal the material basis and mechanism of TCM prescription can we really clarify the scientific connotation of TCM Yao Xinsheng stressed that the essence of traditional Chinese medicine should be grasped in the research of traditional Chinese medicine, and the research of component traditional Chinese medicine should be carried out under the guidance of the theory of traditional Chinese medicine As a kind of medicine, component Chinese medicine must meet the quality requirements of safety, effectiveness, stability and controllability He suggested that the current research should start from the group of active ingredients related to efficacy, and establish the effectiveness, safety and stability control indicators to achieve the quality control of traditional drugs Experts at the meeting pointed out that it is an important prerequisite for promoting the standardization and standardization of traditional Chinese medicine to carry out the research on the material basis and mechanism of traditional Chinese medicine and reveal the scientific connotation of traditional Chinese medicine, which is the main content of the innovation research of traditional Chinese medicine The state should attach great importance to this, list it as a major basic research project, do a good job in long-term planning and top-level design, and actively promote it in a planned and step-by-step manner.