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Tau pathology is closely related to cognition, especially the memory performance of Alzheimer's disease (AD)
Research on the structure of memory function has identified two main cortical memory networks, which are highly connected to the hippocampus and participate in image memory to varying degrees-the anterior temporal system and the posteromedial system
Neurofibrillary tangles first appeared in the transtemporal area, which is a sub-area within the temporal lobe, which mainly overlaps with Brodmann 35 area, and also appears in the temporal lobe cortex
As part of the Swedish BioFINDER-2 study, the study included 215 Aβ- cognitively disabled persons, 81 Aβ+ cognitively disabled persons, and 87 Aβ+ mild cognitively impaired persons.
Event-based modeling showed that the inner cortex and Brodmann 35 area showed the earliest signs of tau accumulation, followed by the anterior and posterior hippocampus, Brodmann 36 area and parahippocampal cortex
In the later stages, tau accumulates abnormally in the temporal and final parietal brain regions of the neocortex
Abnormal sequence of biomarkers in non-dementia elderly
In addition, the reduction of tau-related functional connections in the key network between the medial temporal lobe and the mid-posterior system area is related to this early memory impairment
In addition, the reduction of tau-related functional connections in the key network between the medial temporal lobe and the mid-posterior system area is related to this early memory impairment
In summary, the results of this study emphasize the progression of tau pathology in the medial temporal lobe and its phased association with memory manifestations
references:
Early stages of tau pathology and its associations with functional connectivity, atrophy and memory, Brain, Volume 144, Issue 9, September 2021, Pages 2771–2783, https://doi.
Early stages of tau pathology and its associations with functional connectivity, atrophy and memory,
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