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Sleep monitoring may provide a marker for future Alzheimer's disease (AD) ; however, in preclinical and early symptomatic AD patients, the relationship between sleep and cognitive function is not very clear
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A number of studies have linked short and long sleep periods with future cognitive impairment
Sleep monitoring may provide a marker for future Alzheimer's disease (AD) Sleep monitoring may provide a marker for future Alzheimer's disease (AD)
Since the risks of sleep and AD change with age, it is necessary to further understand how the relationship between sleep and cognition changes over time
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Recently, experts from the Department of Neurology at the University of Washington School of Medicine have hypothesized that longitudinal changes in cognitive function will be related to total sleep time, non-rapid eye movement sleep (NREM) and rapid eye movement sleep (REM) time, sleep efficiency, and non-rapid eye movement sleep.
Because the risks of sleep and AD change with age, and because the risks of sleep and AD change with age,
To test this hypothesis, the researchers monitored 4-6 nights of sleep-wake activity in 100 participants.
These participants received standardized cognitive tests, APOE genotyping, AD biomarkers, and CSF longitudinally.
The measurement of total tau and Aβ42
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In order to assess cognitive function, patients must complete neuropsychological tests at each clinical visit, including free and prompt selective memory tests, logical memory delayed recall assessment, number sign substitution test, and mini mental state examination
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In the cohort, each of these four tests was scored with Z-score, and the average value was used to calculate the comprehensive cognitive score of preclinical AD
The results show that even after adjusting for age, CSF total tau/Aβ42 ratio, APOE ε4 carrier status, years of education, and gender, sleep time alone is enough to affect the changes in brain cognitive abilities—at 7-8 hours of sleep duration The risk of cognitive impairment is the lowest
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Sleep time alone is enough to affect the changes in the brain's cognitive abilities-the risk of cognitive impairment is lowest at 7-8 hours of sleep
The longitudinal changes in cognitive function measured by the comprehensive cognitive indicators are in total sleep time (P<0.
Sleep mode affects the specific mechanism of AD
In the middle range of total sleep time, non-rapid eye movement sleep and rapid eye movement sleep time, and <1Hz slow wave activity, cognitive function stabilized over time, indicating that certain levels of sleep are essential for maintaining cognitive function Very important
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In summary, improving sleep efficiency rather than sleep duration is the most critical factor in preventing cognitive decline
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In summary, improving sleep efficiency rather than sleep duration is the most critical factor in preventing cognitive decline
references:
Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease , Brain, Volume 144, Issue 9, September 2021, Pages 2852–2862, https://doi.
Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease in this message
