Brain: Scientists have discovered a new type of dementia- LATE disease.

SEPTEMBER 17, 2020 // -- In a recent study published in the international journal Brain, scientists from the University of Kentucky and others successfully distinguished between subseconds of multiple brain diseases induced by dementia in a joint study that for the first time developed a standard to distinguish between FTD, frontotemporal dementia and a common Alzheimer's "imitation" - LATE disease.
photo source: Mark Cornelison. UKphoto researchers point out that LATE disease refers to the major age-related TDP-43 encephalopathy (limbic-predominant age-related TDP-43 encephalopathy), which is very similar to the symptoms of Alzheimer's disease, often referred to as dementia, but is induced by different pathogenesis in the brain.
is important because it affects the health of millions of people, about 40 percent of whom are over 85 years old; Researchers from around the world found in autopsies that many people who died in old age had symptoms of dementia, but did not have the visible features of Alzheimer's disease in their brains, such as fiber tangles and amyloid plaques, which recently showed that it was the TDP-43 protein that caused the phenomenon.
Nelson, a research researcher, says many different viruses and bacteria cause pneumonia, so why do we think there's only one cause of dementia? With this in common, researchers are working on new diagnostic standards and other guidelines to advance the naming of the new type of dementia.
'We used to think that the decline in memory and thinking function associated with aging meant one thing, Alzheimer's disease, but now we know that what we call Alzheimer's disease is actually a number of different diseases,' the researchers said. If so, where do the researchers go, cancer has inspired scientists a lot, because in some ways research in the field of cancer is decades ahead of research in the field of dementia; Now that researchers are focusing on the different diseases that trigger dementia, they have found that the accumulation of a protein called TDP-43 in the brain can have harmful effects on the brain and can trigger dementia syndrome, which is characterized by memory loss and thinking problems in the brain.
researchers point out that it is widely believed that millions of people worldwide are affected by age-related TDP-43 conditions, but there may be serious gaps in the classification guidelines for specific neurodegenerative diseases, which is why researchers spend time comparing the differences between FTD and their similar disease, LATE, because the two diseases do have different pathological characteristics.
unless we can define a disease, it will be difficult to find a cure.
Based on the results of this paper, researchers hope to conduct the first clinical trial of THE disease later, which may be a very meaningful opportunity to help researchers test whether new drugs can inhibit the progression of the disease;
() Original source: John L Robinson, Sílvia Porta, Filip G Garrett, et al. Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration, Brain (2020). DOI: 10.1093/brain/awaa219.