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Cerebral small blood vessel disease (CSVD) is a common disease that primarily affects the brain microvessels.
Vessels has been demonstrated CSVD is the leading cause in the world vascular dementia, which typically characterized magnetic resonance imaging (MRI) signal high white matter has been demonstrated CSVD is the leading cause in the world vascular dementia, which typically Characterized by white matter hyperintensity on magnetic resonance imaging (MRI)
Data show that as many as 50% of patients with CSVD and 92% of patients with vascular dementia have apathy-this is a debilitating neuropsychiatric syndrome.
Data show that as many as 50% of patients with CSVD and 92% of patients with vascular dementia have apathy-this is a debilitating neuropsychiatric syndrome.
For this reason, some scholars have put forward the hypothesis that indifference is related to the interruption of decision-making in effort-based decision-making, and that these changes are related to abnormalities in the white matter network connecting the brain regions that support these decisions.
That is, indifference is related to the interruption of decision-making in effort-based decision-making, and these changes are related to abnormalities in the white matter network that connects the brain regions that support these decisions.
Effort-based decisions-tasks and overall performance as a function of indifference.
Effort-based decisions-tasks and overall performance as a function of indifference.
In general, the indifferent patients accept far fewer proposals in this decision-making task.
Researchers have also observed that a significant decrease in white matter integrity is particularly associated with apathy, but not depression.
Use white matter lesion burden to quantify disease severity
Use white matter lesion burden to quantify disease severityThese findings demonstrate the changes in effort-based reward decisions in patients with apathy, and also emphasize that the mechanisms behind apathy and depression can be distinguished in CSVD.
These findings demonstrate the changes in effort-based reward decisions in patients with apathy, and also emphasize that the mechanisms behind apathy and depression can be distinguished in CSVD.
references:
silverchair.
silverchair.
com/awab013.
pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAqIwggKeBgkqhkiG9w0BBwagggKPMIICiwIBADCCAoQGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMsbc1VKMywEreS5ShAgEQgIICVbjyn2JHdNubKzLq8VS1CkOEPebRZAJUT6TKgwe_p2_8P5Wqw8yBIIYmI0fH_h5VWgoarSVcppt-qjPAtqUym6POLA1uSEQf11Qdw4v_SzinJ12UADI8wF815NbZHgHeSmBtoe0PZNI0jSMuufL14flzn1wKKFg3IzXSHACmUDpkeR7HoSJrufs0Xg0HhrVVjDJ_mF-hcHe-23oKAvqDe9YKaY5sljv1yLHlQ0qeDWVh6WAt2JmW9KVOY7DJOunvLjdRtUA4_wJTIKJF5vUY8PE-5sIkHMmrYlFUVI_txwrXGXRVkcOPcrmnt-5KeZmLvQJzLTdJXlFG9RZPG7KP4v49UVABCe-u9nH-hWCU8nPpmeXMBvFPW6-PTVjhN4-7cjDQFwf4POC3SCHtaUWnCguCRBqa2Wa2C3bZQKyAUWLIJ1EjPnBzvRr0-uZ8pVB1PKt5TBKWCbB_HEuufk4cvw3sATvAy7Ogo17fuiEq16MDIDRbvHqsIsjscawhyYuLiWLmyD39poufooppBi2K-sUxcVvDhC3uqIRO_IR5FHKJ3PAHrCrFnmjTGnT25CAKyLKqOL8L1yEyUQJApwgGQEcEBwyMZWPgykuyk8rjOfTyRznmQCIp4jjqhb6V3EdJrt1cRSQgjE3wnGk36Js-7rus6XBF2E9dRTruf3jqZCpdalU0EL9KssLtQLGaCn6QhUGCUnXURRtzgjspIupdVlgWGxEcCkDtIgNqKLyz8nWAbyDKHzT8U7STh4Edg6zBXmhgeyiDCJ8hxa0UhO7-lVZThra_Vg" target="_blank" rel="noopener">Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making.
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