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Brain: Pathological severity of AD covariation and potential genetics affect AD grouping and treatment

 Last Update: 2021-11-13
 Source: Internet
 Author: User

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Lewy body dementia (DLB) is a fatal neurological disease characterized by a combination of cognitive fluctuations, Parkinson's disease, visual hallucinations, and rapid eye movement behavior disorder
.

This type of dementia is one of the most common neurological diseases in the general population, accounting for approximately 7.

APOE sites are closely related to the risk of Alzheimer's disease and Lewy body (DLB) dementia
.

In particular, the role of the apolipoprotein eε4 allele as a presumptive driving factor of α-synuclein pathology is a hotly debated topic

Karri Kaivola et al
.

conducted a comprehensive evaluation of 2466 DLB patients and 2928 neurologically healthy elderly controls .

Karri Kaivola et al

Karri Kaivola like APOE-stratified using genome-wide association study found that the method, the relevant (p = 6.
58 x 10 GBA DLB patients with no risk of APOE ^{-.
9} = 3.
41 for, 95% CI = 2.
25-5.
17), but not with patients with DLB APOE ( p = 0.
034, = 1.
87, 95%, 95% CI = 1.
05-3.
37)
.

^{- 9}

Analytical method

Demographic characteristics of DLB subgroups

Then 495 cases were divided into three groups based on the accompanying pathological changes of AD comorbidities: pure DLB (n = 88), DLB-intermediate AD comorbidity (DLB+iAD, n = 66), and DLB-advanced AD comorbidity (DLB+ AD,n = 341)
.

Except for 2928 neurological healthy controls, the correlation of apolipoprotein e ε4 in each group was tested
.

The study found that APOEε4 is related to DLB+AD (p = 1.
29 x10 ^-32 , OR=4.
25, 95% CI = 3.
35-5.
39) and DLB+ iAD (p = 0.
0011, = 2.
31, 95% CI 3.
83 = 1.
40), but with pure DLB is irrelevant ( p = 0.
31, OR=0.
75, 95% CI 1.
30 = 0.
43)
.

APOEε4 is related to DLB+AD (p = 1.
29 x10 ^-32 , OR=4.
25, 95% CI = 3.
35-5.
39) and DLB+ iAD (p = 0.
0011, = 2.
31, 95% CI 3.
83 = 1.
40), but has nothing to do with pure DLB ( p = 0.
31, OR=0.
75, 95% CI 1.
30 = 0.
43)
.

^-32p

This study shows that APOE ε4 is not an independent driving factor of α-synuclein pathology in DLB
.

On the contrary, the severity of AD covariation pathology affects the correlation of APOE ε4

The severity of

Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups, Brain, 2021;, awab402, https://doi.

Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups, Brain, 2021 ;, awab402, https://doi.
org/10.
1093/brain/awab402 in this message

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