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Brain: oligodendrocyte exosome secretion in multisystem atrophy involves SNARE dysfunction

 Last Update: 2022-09-30
 Source: Internet
 Author: User

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Recently, the team of Professor Zhang Jing from Zhejiang University School of Medicine published an article in Brain Journal reporting on the relationship between
oligodendrocyte exosome secretion and pathological α-syn aggregation and SNARE complex dysfunction in multisystem atrophy (MSA).

Multisystem atrophy (MSA) is a rare neurodegenerative disease characterized by autonomic dysfunction, parkinsonism, cerebellar impairment, and cone bundle signs
.

Although there is still a lack of complete understanding of the underlying pathogenesis of MSA, a-syn aggregation appears to be at least one contributing factor
.

These findings suggest that extracellular vesicles and their a-syn cargo may undergo similar alterations
in MSA.

The study developed a novel immunocapture technique to isolate CNPase-positive, oligodendrocyte-derived enriched microvesicles (OEMVs) in the blood, followed by fluorescent nanoparticle-tracking analysis and assessment of α-syn levels
contained in OEMVs.

A-Syn-syntaxin4 interactions regulate SNARE complex function and exosome secretion

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