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Annemarie Dedek, Eve Tsai and Mike Hildebrand (left to right) show for the first time that neurons in the spinal cord of women process pain signals differently than men
A new study published in the journal Brain shows for the first time that neurons in the spinal cord of women process pain signals differently than men
Although it has long been known that women and men experience pain differently, most pain studies have used male rodents
By examining spinal cord tissue in the lab, the researchers were able to show that a nerve growth factor called BDNF plays an important role in amplifying pain signals in the spinal cord in men and mice, but not in women and mice.
"Developing new pain medications requires a detailed understanding of how pain is handled at the biological level," said Dr.
This is the first time that gender-related pain signaling differences have been found in human spinal cord tissue
article title
Amphimorphic neural mechanisms of spinal cord hyperexcitability in rodent and human pain models
