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There is great interest in the possibility of progressive neurological deterioration due to traumatic brain injury
There is great interest in the possibility of progressive neurological deterioration due to traumatic brain injury
Virginia FJ Newcombe et al.
The research team recruited 203 patients in two different cohorts; six months post-injury (n=165); and >5 years post-injury (n=38; 12 of them also provided 8 months post-TBI data)
The research team recruited 203 patients in two different cohorts; six months post-injury (n=165); and >5 years post-injury (n=38; 12 of them also provided 8 months post-TBI data)
Data from the patient cohort were compared with 59 healthy volunteers and 21 non-brain trauma trauma controls
Gray matter (Panel A) and white matter (Panel B) VBM results of patients and controls more than 5 years after traumatic brain injury
Gray matter (Panel A) and white matter (Panel B) VBM results of patients and controls more than 5 years after traumatic brain injury
Whole brain gray matter and whole brain white matter in subgroups of patients who showed improvement (1 point increase in GOSE), stable (no change in GOSE), or worsening (1 point decrease in GOSE) between 8 months and 5 years after injury (Fig.
Whole brain gray matter and whole brain white matter in subgroups of patients who showed improvement (1 point increase in GOSE), stable (no change in GOSE), or worsening (1 point decrease in GOSE) between 8 months and 5 years after injury (Fig.
The study found:
- Elevated serum neurofilament light chain concentrations in the early stages of chronicity
In conclusion, this study demonstrates that glial fibrillary acidic protein and neurofilament light chain levels can remain elevated for months to years after traumatic brain injury, showing a distinct temporal distribution
original sourceVirginia FJ Newcombe, Nicholas J.
Virginia FJ Newcombe, Nicholas J.
Ashton, Jussi P.
Posti, Ben Glocker, Anne Manktelow, Doris A.
Chatfield, Stefan Winzeck, Edward Needham, Marta M.
Correia, Guy B.
Williams, Joel Simrén, Riikka SK Takala, Ari J .
Katila, Henna-Riikka Maanpää, Jussi Tallus, Janek Frantzén, Kaj Blennow, Olli Tenovuo, Henrik Zetterberg, David K.
Menon, Post-acute blood biomarkers and disease progression in traumatic brain injury, Brain , 2022;, awac126, https: //doi.
org/10.
1093/brain/awac126 Brain https://doi.
org/10.
1093/brain/awac126
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