Brain damage caused by cerebral amyloid vascular disease is caused by leakage of blood-brain barrier

Little is known about the pathophysiological mechanisms of CAA and CAA-related bleedingWhitney MFreeze of maastricht University's School of Mental Health and Neuroscience, in the Netherlands, and others examined the association between blood-brain barrier leakage and CAA and microvascular lesions through autopsies, published in The February 2019 issue of Stroke- From the article chapter: Freeze WM, et alStroke2019 Feb; 50 (2): 328-335doi: 10.1161/STROKEAHA.118.023788.)brain amyloid disease (cerebral amyloid anpathy, CAA) is a common small vascular disease that affects the function of the elderlyLittle is known about the pathophysiological mechanisms of CAA and CAA-related bleedingWhitney MFreeze of maastricht University's School of Mental Health and Neuroscience, in the Netherlands, and others examined the association between blood-brain barrier leakage and CAA and microvascular lesions through autopsies, published in The February 2019 issue of StrokeA total of 11 CAA patients were included in theAge 65-79 years, median 69 years of age, of which 8 males, 7 cases of no neurological disease or brain lesions were selected for a controlled study, aged 68-92 years, median age 77 years, of which 4 were maleSamples were taken from each cerebral cortex slice and isochemically assessed for IgG and fibrin osmosisThe researchers hypothesized that the epitome of the leakage of the blood-brain barrier in CAA patients, immunoglobulin G (IgG) and fibrin, was significantly higher than the prefrontal region, and was associated with the number of cerebral microhems (cerebral microbleeds, CMBbs) and cerebral micro-infarctions (micro-deficiacs) in MRI imagingresults showed an increase in IgG positive rates in the frontal temporal lobes (P - 0.044) and pillow lobes (P - 0.001) cortex compared to the control group Compared with the frontal temporal lobe, the fibrin and IgG positive rates of the pillow lobe increased (P-0.005, P-0.006) The percentage of positive blood vessels for fibrin and IgG is related to the percentage of amyloid-beta-positive blood vessels (Spearman s.71, P-0.015 and Spearman s.03, P-0.011) In addition, the percentage of fibrin and IgG-positive blood vessels is associated with the amount of micro-bleeding in the brain (Spearman s.77, P-0.005 and Spearman-0.70, P-0.017) The researchers observed fibrin deposits in the walls of blood vessels where the brain is slightly bleeding , the researchers believe that the leak of the blood-brain barrier may be the CAA's mechanism for brain damage.