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March 26, 2021 //---In a recent study, through the analysis of adult brain tissue, researchers revealed more than 900 proteins related to epilepsy.
Led by researchers at New York University’s Grossman School of Medicine, the study examined molecular differences in the brains of 14 epilepsy patients and another group of 14 healthy adults.
Led by researchers at New York University’s Grossman School of Medicine, the study examined molecular differences in the brains of 14 epilepsy patients and another group of 14 healthy adults.
The results of the study show that the changes in brain protein levels in the hippocampus of the brain are the largest.
The hippocampus is located deep in the skull and is responsible for memory and learning.
Approximately 134 proteins in the frontal cortex of the hippocampus and the first third of the brain have undergone significant changes, and 4 of the 20 most changed proteins have never been reported to have any connection with epilepsy before.
The hippocampus is located deep in the skull and is responsible for memory and learning.
Approximately 134 proteins in the frontal cortex of the hippocampus and the first third of the brain have undergone significant changes, and 4 of the 20 most changed proteins have never been reported to have any connection with epilepsy before.
(Image source: www.
pixabay.
com)
pixabay.
com)
Researchers say that a special protein is most consumed in all brain regions.
This protein is called G protein subunit 1 (GNB1) and plays an important role in dozens of biological reactions or pathways involving nerve growth and communication throughout the brain, but its exact role in epilepsy is still unclear.
This protein is called G protein subunit 1 (GNB1) and plays an important role in dozens of biological reactions or pathways involving nerve growth and communication throughout the brain, but its exact role in epilepsy is still unclear.
Relevant results were recently published in "Brain Communications" magazine.
Co-author and senior researcher Dr.
Orrin Devinsky said: "Our analysis identified hundreds of potential new treatment targets for epilepsy, with a focus on the brain regions damaged by the disease.
Although our findings indicate that the hippocampus is the most vulnerable to epilepsy.
However, further research is needed to confirm whether this area is the main source of the disease and how epilepsy affects other diseases such as dementia and depression.
”
Orrin Devinsky said: "Our analysis identified hundreds of potential new treatment targets for epilepsy, with a focus on the brain regions damaged by the disease.
Although our findings indicate that the hippocampus is the most vulnerable to epilepsy.
However, further research is needed to confirm whether this area is the main source of the disease and how epilepsy affects other diseases such as dementia and depression.
”
Co-author Wisniewski of the article is Professor Gerald J.
and Dorothy R.
Friedman of the Department of Neurology and director of the Center for Cognitive Neurology at New York University Langen.
He said that the GNB1 pathway has become a target for more than a dozen drugs.
Wisniewski said the New York University team plans to build a database to map "brain pictures" of epileptic proteins and gene targets.
They also plan to conduct preliminary clinical studies to determine how existing drugs that alter GNB1 can prevent or treat the disease.
(Bioon.
com)
and Dorothy R.
Friedman of the Department of Neurology and director of the Center for Cognitive Neurology at New York University Langen.
He said that the GNB1 pathway has become a target for more than a dozen drugs.
Wisniewski said the New York University team plans to build a database to map "brain pictures" of epileptic proteins and gene targets.
They also plan to conduct preliminary clinical studies to determine how existing drugs that alter GNB1 can prevent or treat the disease.
(Bioon.
com)
Information source: com/news/2021-03-key-proteins-linked-epilepsy-revealing.
html">Study maps key proteins linked to epilepsy, revealing new drug targets
html">Study maps key proteins linked to epilepsy, revealing new drug targets
Original source: Geoffrey Pires, Dominique Leitner, Eleanor Drummond et al, oup.
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
(Image source: www.
pixabay.
com)
pixabay.
com)
Researchers say that a special protein is most consumed in all brain regions.
This protein is called G protein subunit 1 (GNB1) and plays an important role in dozens of biological reactions or pathways involving nerve growth and communication throughout the brain, but its exact role in epilepsy is still unclear.
This protein is called G protein subunit 1 (GNB1) and plays an important role in dozens of biological reactions or pathways involving nerve growth and communication throughout the brain, but its exact role in epilepsy is still unclear.
Relevant results were recently published in "Brain Communications" magazine.
Co-author and senior researcher Dr.
Orrin Devinsky said: "Our analysis identified hundreds of potential new treatment targets for epilepsy, with a focus on the brain regions damaged by the disease.
Although our findings indicate that the hippocampus is the most vulnerable to epilepsy.
However, further research is needed to confirm whether this area is the main source of the disease and how epilepsy affects other diseases such as dementia and depression.
”
Orrin Devinsky said: "Our analysis identified hundreds of potential new treatment targets for epilepsy, with a focus on the brain regions damaged by the disease.
Although our findings indicate that the hippocampus is the most vulnerable to epilepsy.
However, further research is needed to confirm whether this area is the main source of the disease and how epilepsy affects other diseases such as dementia and depression.
”
Co-author Wisniewski of the article is Professor Gerald J.
and Dorothy R.
Friedman of the Department of Neurology and director of the Center for Cognitive Neurology at New York University Langen.
He said that the GNB1 pathway has become a target for more than a dozen drugs.
Wisniewski said the New York University team plans to build a database to map "brain pictures" of epileptic proteins and gene targets.
They also plan to conduct preliminary clinical studies to determine how existing drugs that alter GNB1 can prevent or treat the disease.
(Bioon.
com)
and Dorothy R.
Friedman of the Department of Neurology and director of the Center for Cognitive Neurology at New York University Langen.
He said that the GNB1 pathway has become a target for more than a dozen drugs.
Wisniewski said the New York University team plans to build a database to map "brain pictures" of epileptic proteins and gene targets.
They also plan to conduct preliminary clinical studies to determine how existing drugs that alter GNB1 can prevent or treat the disease.
(Bioon.
com)
Information source: com/news/2021-03-key-proteins-linked-epilepsy-revealing.
html">Study maps key proteins linked to epilepsy, revealing new drug targets
html">Study maps key proteins linked to epilepsy, revealing new drug targets
Original source: Geoffrey Pires, Dominique Leitner, Eleanor Drummond et al, oup.
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
Relevant results were recently published in "Brain Communications" magazine.
Co-author and senior researcher Dr.
Orrin Devinsky said: "Our analysis identified hundreds of potential new treatment targets for epilepsy, with a focus on the brain regions damaged by the disease.
Although our findings indicate that the hippocampus is the most vulnerable to epilepsy.
However, further research is needed to confirm whether this area is the main source of the disease and how epilepsy affects other diseases such as dementia and depression.
”
Orrin Devinsky said: "Our analysis identified hundreds of potential new treatment targets for epilepsy, with a focus on the brain regions damaged by the disease.
Although our findings indicate that the hippocampus is the most vulnerable to epilepsy.
However, further research is needed to confirm whether this area is the main source of the disease and how epilepsy affects other diseases such as dementia and depression.
”
Co-author Wisniewski of the article is Professor Gerald J.
and Dorothy R.
Friedman of the Department of Neurology and director of the Center for Cognitive Neurology at New York University Langen.
He said that the GNB1 pathway has become a target for more than a dozen drugs.
Wisniewski said the New York University team plans to build a database to map "brain pictures" of epileptic proteins and gene targets.
They also plan to conduct preliminary clinical studies to determine how existing drugs that alter GNB1 can prevent or treat the disease.
(Bioon.
com)
and Dorothy R.
Friedman of the Department of Neurology and director of the Center for Cognitive Neurology at New York University Langen.
He said that the GNB1 pathway has become a target for more than a dozen drugs.
Wisniewski said the New York University team plans to build a database to map "brain pictures" of epileptic proteins and gene targets.
They also plan to conduct preliminary clinical studies to determine how existing drugs that alter GNB1 can prevent or treat the disease.
(Bioon.
com)
Information source: com/news/2021-03-key-proteins-linked-epilepsy-revealing.
html">Study maps key proteins linked to epilepsy, revealing new drug targets
html">Study maps key proteins linked to epilepsy, revealing new drug targets
Original source: Geoffrey Pires, Dominique Leitner, Eleanor Drummond et al, oup.
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
Co-author and senior researcher Dr.
Orrin Devinsky said: "Our analysis identified hundreds of potential new treatment targets for epilepsy, with a focus on the brain regions damaged by the disease.
Although our findings indicate that the hippocampus is the most vulnerable to epilepsy.
However, further research is needed to confirm whether this area is the main source of the disease and how epilepsy affects other diseases such as dementia and depression.
”
Orrin Devinsky said: "Our analysis identified hundreds of potential new treatment targets for epilepsy, with a focus on the brain regions damaged by the disease.
Although our findings indicate that the hippocampus is the most vulnerable to epilepsy.
However, further research is needed to confirm whether this area is the main source of the disease and how epilepsy affects other diseases such as dementia and depression.
”
Co-author Wisniewski of the article is Professor Gerald J.
and Dorothy R.
Friedman of the Department of Neurology and director of the Center for Cognitive Neurology at New York University Langen.
He said that the GNB1 pathway has become a target for more than a dozen drugs.
Wisniewski said the New York University team plans to build a database to map "brain pictures" of epileptic proteins and gene targets.
They also plan to conduct preliminary clinical studies to determine how existing drugs that alter GNB1 can prevent or treat the disease.
(Bioon.
com)
and Dorothy R.
Friedman of the Department of Neurology and director of the Center for Cognitive Neurology at New York University Langen.
He said that the GNB1 pathway has become a target for more than a dozen drugs.
Wisniewski said the New York University team plans to build a database to map "brain pictures" of epileptic proteins and gene targets.
They also plan to conduct preliminary clinical studies to determine how existing drugs that alter GNB1 can prevent or treat the disease.
(Bioon.
com)
Information source: com/news/2021-03-key-proteins-linked-epilepsy-revealing.
html">Study maps key proteins linked to epilepsy, revealing new drug targets
html">Study maps key proteins linked to epilepsy, revealing new drug targets
Original source: Geoffrey Pires, Dominique Leitner, Eleanor Drummond et al, oup.
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
Co-author Wisniewski of the article is Professor Gerald J.
and Dorothy R.
Friedman of the Department of Neurology and director of the Center for Cognitive Neurology at New York University Langen.
He said that the GNB1 pathway has become a target for more than a dozen drugs.
Wisniewski said the New York University team plans to build a database to map "brain pictures" of epileptic proteins and gene targets.
They also plan to conduct preliminary clinical studies to determine how existing drugs that alter GNB1 can prevent or treat the disease.
(Bioon.
com)
and Dorothy R.
Friedman of the Department of Neurology and director of the Center for Cognitive Neurology at New York University Langen.
He said that the GNB1 pathway has become a target for more than a dozen drugs.
Wisniewski said the New York University team plans to build a database to map "brain pictures" of epileptic proteins and gene targets.
They also plan to conduct preliminary clinical studies to determine how existing drugs that alter GNB1 can prevent or treat the disease.
(Bioon.
com)
Information source: com/news/2021-03-key-proteins-linked-epilepsy-revealing.
html">Study maps key proteins linked to epilepsy, revealing new drug targets
html">Study maps key proteins linked to epilepsy, revealing new drug targets
Original source: Geoffrey Pires, Dominique Leitner, Eleanor Drummond et al, oup.
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
Information source: com/news/2021-03-key-proteins-linked-epilepsy-revealing.
html">Study maps key proteins linked to epilepsy, revealing new drug targets
Information source: com/news/2021-03-key-proteins-linked-epilepsy-revealing. html">Study maps key proteins linked to epilepsy, revealing new drug targets
html">Study maps key proteins linked to epilepsy, revealing new drug targets
Original source: Geoffrey Pires, Dominique Leitner, Eleanor Drummond et al, oup.
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
Original source: Geoffrey Pires, Dominique Leitner, Eleanor Drummond et al, oup.
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
：oup. com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissue , Brain Communications (2021).
DOI: 10.
1093/braincomms/fcab021
com/braincomms/advance-article/doi/10.
1093/braincomms/fcab021/6159319">Proteomic differences in the hippocampus and cortex of epilepsy brain tissueBrain Communications
