Brain commin: the immune system actually promotes the spread of brain tumors!

January 26, 2020 / BIOON / -- in a study published in the journal Brain communications, a research team led by Carlos barcia, a researcher at the Institute of neuroscience of Barcelona Autonomous University, analyzed the role of immune cells in the expansion of glioblastoma This study is the first to show that microglia and macrophages are the cells of the immune system By clearing the necrotic area of the tumor and ignoring the existence of tumor cells, the invasion ability of glioblastoma is promoted This invasive tumor mass is part of a tumor that comes into contact with healthy tissue It's shaped like a false fence and is difficult to flush with blood vessels This leads to hypoxia, escape of tumor cells and invasion of healthy tissues, and formation of necrotic areas within the tumor In this study, the researchers showed that microglia and macrophages can enter these hypoxic areas, and only clean dying tumor cells, thus promoting tumor growth and expansion "The importance of this work is that, for the first time, we have observed the presence of immune system cells in the infiltrating areas of these specific tumors, and the phagocytic capacity of immune cells has not been lost, so we can promote tumor clearance through training." The next step is to study how microglia and macrophages can be trained through immunotherapy or other strategies to help eliminate cancer without promoting its growth Information source: immune system cells contribute to the investing capacity of brain tubes original source: Elena saavedra-l ó PEZ et al Pharmaceutical glioblastoma associated microglia and macrophases popular investing pseudopalisades, brain communications (2019) Doi: 10.1093/braincomms/fcz043