BRAIN: Brain TSPO-PET predicts the recurrence of multiple sclerosis

Overactivation of small glial cells is associated with most neurodegenerative diseases.
study, we examined whether PET's measurable innate immune cell activation predicted the progression of multiple sclerosis.
69 patients with multiple sclerosis and 18 healthy controls of age and gender matching were biomassed with radioactive ligation 11C-PK11195 and PET imaging combined with 18 kDa potential proteins (TSPO).
the distribution volume ratio of a dynamic PET image by combining a radiological complex.
used an extended disability status scale to perform routine MRI and disability measurements on patients with baselines and 4.1 years ±1.9 years (average ± standard deviation).
51 patients (74%) did not relapse during follow-up.
compared to the healthy control group, patients had increased activation of inherent immune cells in the normally occurring whiteness and pausculoid brain (Wilcoxon, P, 0.033, and P, 0.003, respectively).
progressive logical regression is used to evaluate the best variables for predicting disease progression.
When evaluating the entire multiple sclerosis queue, baseline innate immune cell activation in normal whiteness is an important predictive indicator of late progress.
in the non-recurring patient subgroup, there was an association between macrophage/small glial cell activity in whiteness that normally appeared around the lesions and disease progression (OR s 4.57; P s 0.013).
MRI parameters for baseline measurements were not associated with subsequent progress.
results strongly suggest that innate immune cell activity leads to diffuse nerve damage, leading to the progression of multiple sclerosis disease is not related to recurrence.
original origins: Marcus Sucksdorff, Markus Matilainen, Jouni Tuisku, BRAIN TSPO-PET predictors later disease progression independent of relapses in multiple sclerosis. MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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