Br J Haematol: The tumor disappeared after a patient with advanced Hodgkin's lymphoma contracted the new coronavirus

A 61-year-old patient with severe kidney disease and advanced Hodgkin's lymphoma disappeared four months after contracting the new coronavirus.
the British Journal of Hematology recently published this case report.
the 61-year-old, who suffers from severe kidney disease, had a kidney transplant three years ago but failed and has been relying on dialysis ever since.
while he was in hospital, he was found to have advanced Hodgkin's lymphoma and had metastatic, and a CT scan showed active cancer cells all over his body.
, shortly after he was diagnosed with terminal cancer, he developed symptoms of breathing difficulties and wheezing, and was later diagnosed with neo-crown pneumonia.
after 11 days in hospital, he was discharged from the hospital and sent home to recuperate.
, however, just four months later, CT reviews revealed that most of the tumors in the patient's body had disappeared and that levels of tumor-related biomarkers had dropped by more than 90 percent.
he had not been treated with any immunotherapy and corticosteroids during this time.
, although there have been precedents for cancer patients to have their tumors disappear after contracting other diseases, such cases are still very rare.
researchers have not yet identified the cause of the tumor's disappearance, but they hypothesized that infection with the new coronavirus triggered an anti-tumor immune response in the patient's body.
, however, is still speculative and the exact mechanism is unclear.
In fact, there have been previous reports that the patient also has a history of non-Hodgkin's lymphoma and that the patient's serum response has been negative since infection with SARS-CoV-2, i.e. the inability to produce antibodies.
treated with restorative plasma after treatment.
the case was a 63-year-old woman with a history of non-Hodgkin's lymphoma, remission while receiving maintenance therapy for anti-CD20 monoclonal antibody obinutuzumab, and detection of SARS-SARS-through nasopharyngeal reverse transcription polymerase chain reaction CoV-2 positive (RT-PCR) tested for more than 12 weeks and serum-negative testing of immunoglobulin G (IgG) antibodies was performed using SARS-CoV-2 IgG chemical luminescent particle immunoanalysis.
this time, patients experienced fluctuations and abating symptoms, including fever, myalgia and unsectoral cough, but never severe respiratory distress.
she fell ill on the 88th day and was taken to our hospital, where her symptoms disappeared after taking restorative plasma.
with the continuous development of understanding of the pathogenesis of SARS-CoV-2, we can only speculate on the relationship between chronic infection and re-infection.
protective effects of antibodies and their lifetime of SARS-CoV-2 are unclear.
seems to indicate that there may be some interaction between the new coronavirus and non-Hodgkin's lymphoma.
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