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Br J Cancer: SBSN: a potential diagnostic and therapeutic target for bladder cancer

 Last Update: 2022-05-26
 Source: Internet
 Author: User

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Bladder cancer is the most common malignant tumor in the urinary system, accounting for 90%-95% of urothelial cancers

Previous studies have shown that patients with non-muscle invasive bladder cancer have a higher survival rate, with a 5-year progression-free survival rate of 93% in the low-risk group and 54% even in the high-risk group

SBSN (Suprabasin), a gene expressed in mouse and human differentiated keratinocytes, is a marker of epidermal differentiation and a potential precursor of the keratinized envelope

SBSN enhanced the phosphorylation levels of EGFR and SRC kinases, which subsequently affected the phosphorylation and nuclear localization status of STAT3

Zhou, Z.

https://doi.
org/10.
1038/s41416-022-01794-7.

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