Br J Cancer: Prospective study reveals the causal relationship between gallstone disease and gastrointestinal cancer risk

Gallstone disease (GSD) is a major gallbladder disease that affects approximately 10% to 20% of the global adult population.
Traditionally, East Asian countries, including China, are considered areas with low GSD risk (ie female prevalence rate <10%).
A national survey conducted in China in 2008 showed that ultrasound detected 7.
9% of male patients with GSD and 8.
2% of female patients.

Gallstone disease (GSD) is a major gallbladder disease that affects approximately 10% to 20% of the global adult population.
Gallstone disease (GSD) is a major gallbladder disease that affects approximately 10% to 20% of the global adult population.

Gastrointestinal cancer is one of the main causes of cancer incidence and mortality.
In 2017, it caused approximately 3.
6 million deaths worldwide.
Compared with high-income countries, Chinese people’s esophageal cancer,The incidence of gastric cancer and liver cancer is higher, while the incidence of colorectal cancer and pancreatic cancer is even lower.

Gastrointestinal cancer is one of the main causes of cancer incidence and mortality.
In 2017, it caused approximately 3.
6 million deaths worldwide.
Gastrointestinal cancer is one of the main causes of cancer incidence and mortality.
In 2017, it caused approximately 3.
6 million deaths worldwide.
Gastric cancer colorectal cancer pancreatic cancer

Previous studies have shown that GSD is associated with a higher risk of several gastrointestinal (GI) cancers.
However, it is not yet clear whether this correlation is causal.

GSD is associated with a higher risk of several gastrointestinal (GI) cancers.
GSD is associated with a higher risk of several gastrointestinal (GI) cancers.

The study analyzed 17,598 cases of gastrointestinal cancer among 510,137 baseline cancer-free participants recorded by the China Kadoorie Biobank (CKB project) prospective research project for chronic diseases (China Kadoorie Biobank) during a 10-year follow-up period.

Evaluate the risk ratios (HRs) of specific cancers by analyzing GSD status and duration.

The relationship between GSD and gastrointestinal cancer

The relationship between GSD and gastrointestinal cancer

The results showed that 6% of participants had symptomatic GSD at baseline.

Compared with patients without GSD, the risk ratio of colorectal cancer in patients with GSD symptoms is 1.

Compared to participants without GSD , colorectal cancer, liver cancer, gallbladder cancer, cholangiocarcinoma, and pancreatic cancer have the highest risk of developing colorectal cancer, liver cancer, gallbladder cancer, cholangiocarcinoma, and pancreatic cancer within 0 to <5 years after the diagnosis of the disease.

Further research has shown that GSD is genetically related to these cancers.

A meta-analysis of the correlation between GSD and gastrointestinal cancer

A meta-analysis of the correlation between GSD and gastrointestinal cancer

All in all, the results of this study reveal that GSD is associated with a higher risk of several gastrointestinal cancers, so it is necessary to further study its underlying mechanisms.

GSD is associated with a higher risk of several gastrointestinal cancers, so it is necessary to further study its underlying mechanism.
GSD is associated with a higher risk of several gastrointestinal cancers, so it is necessary to further study its underlying mechanism.

Original source:

Pang, Y.

, Lv, J.
, Kartsonaki, C.

org/10.

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