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Hepatocellular carcinoma (HCC) is one of the world's major causes of cancer-related deaths, with a five-year survival rate of only 15% for HCC patients, and more than 80% of HCC patients are diagnosed with advanced and poor prognosis.
growing evidence that liver cancer occurs not only with genetic and genomic changes, but also with changes in metabolism.
, however, the underlying mechanism is unclear.
, in-depth understanding of the relevant molecular basis of HCC, and the development of effective treatment strategies, is conducive to improving patient survival.
liver is a central organ that regulates the steady state of cholesterol, DHCR24 is a key enzyme in the biosynthetic pathway of cholesterol and is involved in the formation of lipid rafts.
(Genkwadaphnin, GD) is a kind of rhyme diazole isolated from the buds of the Thymelaeaceae plantflowers.
the chemical structure of GD used HCC cells and BALB/c naked mouse models to assess the role of GD.
the gene chip to identify the difference expression gene in GD.
the expression and activity of DHCR24, cholesterol levels, lipid raft structure, and the role of DHCR24 in human liver cancer samples through relevant molecular biology experiments.
gene expression maps treated with GD, researchers found that in human liver cancer samples, dhCR24's high expression levels were associated with poor prognosis in patients.
interference with the expression of DHCR24 can inhibit the growth and migration of HCC cells.
GD dosing inhibits the growth and metastasis of HCC cells.
GD can inhibit the expression and activity of DHCR24, as well as ??? The biosynthetic process of DHCR24-mediated cholesterol and the formation of lipid rafts ultimately inhibit the invasion and migration of HCC cells.
GD inhibits the development of liver cancer, the results show that cholesterol metabolism mediated by targeting DHCR24 may be an effective treatment strategy for liver cancer, while natural product GD may be a potential drug for HCC treatment.
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