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Br J Cancer: Metformin can improve the prognosis of patients with gastric adenocarcinoma

 Last Update: 2021-05-31
 Source: Internet
 Author: User

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As a common disease, gastric cancer has a poor overall prognosis.

Gastric adenocarcinoma is the main histological type of gastric cancer (>95%).

The treatment strategy of gastric adenocarcinoma generally adopts a multidisciplinary approach, in which surgical resection (gastrectomy) is the main treatment method, while patients with unresectable or metastatic disease usually adopt chemotherapy and targeted therapies.

Recent studies have shown that metformin, as a first-line drug for diabetes , can improve the prognosis of patients with colon cancer and prostate cancer.

Metformin diabetic colon cancer

Kaplan-Meier survival curve of metformin in the treatment of gastric adenocarcinoma

The researchers assessed the relationship between the use of metformin before diagnosis of gastric adenocarcinoma and the disease-specific mortality and all-cause mortality through multivariate Cox risk regression analysis.

Comparison of cumulative mortality curves between metformin users and non-users

All in all, the results of the study reveal that metformin can improve the survival rate of gastric adenocarcinoma patients with diabetes.

The results of the study revealed that metformin can improve the survival rate of gastric adenocarcinoma patients with diabetes.

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