Br J Cancer: Meta-analysis shows the correlation between diabetes and cancer risk

In 2015, about 415 million people had diabetes , and more than 90% of them had type 2 diabetes, and the prevalence continued to increase and affect all regions and countries around the world .
Risk factors for type 2 diabetes include genetics, age, family history of diabetes, unhealthy diet, obesity, and lack of physical exercise.

In this study, the researchers aimed to investigate whether the association between diabetes and cancer risk is age-related, and how this association differs between subgroups of age, weight status, or physical activity level.

The researchers analyzed the data of seven prospective cohort studies of the European and American Cohort Network (CHANCES) and used the Cox risk regression method to assess the correlation between epidemic diabetes and cancer risk.
And through the meta-analysis and random effects meta-analysis, a summary risk assessment of the entire cohort was calculated.

Meta-analysis of the correlation between diabetes and total cancer risk

The researchers recruited 667,916 participants with an overall median age of 62.
3 (57-67) years.
In an average follow-up time of 10.
5 years, a total of 114,404 cancer cases were identified.
The results showed that diabetes has nothing to do with the overall risk of cancer, but is positively correlated with the risk of male colorectal cancer .

A meta-analysis of the correlation between diabetes and prostate cancer risk

Researchers have found that diabetes is negatively associated with the risk of prostate cancer, but has nothing to do with postmenopausal breast cancer .
In an exploratory subgroup analysis, only in overweight or obese men, diabetes was negatively correlated with the risk of prostate cancer.

All in all, among elderly Europeans and Americans, diabetes is positively correlated with the risk of colorectal cancer and negatively correlated with the risk of prostate cancer.