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Oral squamous cell carcinoma (OSCC) or oral cancer is a major subtype of head and neck cancer and is the leading cause of death among men in Southeast Asia.
Oral squamous cell carcinoma (OSCC) or oral cancer is a major subtype of head and neck cancer Oral squamous cell carcinoma (OSCC) or oral cancer is a major subtype of head and neck cancer
Although you can work by changing habits and ways largely prevention , but in most cases, the adverse clinical manifestations of oral cancer and the prognosis and high mortality.
prevention
Due to the lack of reliable clinical pathology and molecular predictors, the malignant transformation of OSCC is unpredictable.
MCL-1 and USP9X expression are correlated in oral cell lines and tissues
MCL-1 and USP9X expression are correlated in oral cell lines and tissuesResearchers have found that the overexpression of the anti-apoptotic MCL-1 protein in OSCC is related to the occurrence and development of the disease, the development of treatment resistance, and the poor prognosis of the patient.
This study aims to explore the role of deubiquitinating enzyme USP9X in stabilizing MCL-1 protein and its contribution to the occurrence and development of oral cancer.
High expression of MCL-1 and USP9X is associated with poor prognosis of patients
High expression of MCL-1 and USP9X is associated with poor prognosis of patientsThe researchers found that compared with normal mucosa, the expression levels of USP9X and MCL-1 in oral precancerous lesions and oral cancer were significantly higher.
Compared with normal mucosa, the expression levels of USP9X and MCL-1 in oral precancerous lesions and oral cancer are significantly higher.
Elevated USP9X drives early-to-late-stage oral tumorigenesis via stabilisation of anti-apoptotic MCL-1 protein and impacts outcome in oral cancers.
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