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Br J Cancer: Clinical study of Berzosertib combined with cisplatin in the treatment of patients with advanced solid tumors

 Last Update: 2021-06-10
 Source: Internet
 Author: User

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The standard care treatments used to treat a variety of tumors mainly include DNA damage-related chemotherapy drugs.

Previous studies have shown, the ATR (ataxia capillary blood vessel dilation mutated (ATM) and Rad3 related protein kinase) play a crucial role in DNA damage response (DDR), which is capable of regulation by homologous recombination, and cell cycle checkpoint Repair of damaged DNA.

Blood vessel

Berzosertib (M6620, VX-970) is a highly effective and selective ATR inhibitor.

Related research flow chart

The results showed that a total of 31 patients received berzosertib on seven dose levels (90-210μmg / m2) and cisplatin (40-75μmg / m ² ) in combination therapy.

Plasma concentration-time curve of Berzosertib combined with cisplatin

All in all, the results of the study reveal that the combination therapy of berzosertib and cisplatin is well tolerated, and it has shown preliminary clinical activity in patients with advanced solid tumors.

The combination therapy of berzosertib and cisplatin is well tolerated, and it has shown preliminary clinical activity in patients with advanced solid tumors.

Phase 1 study of the ATR inhibitor berzosertib in combination with cisplatin in patients with advanced solid tumours

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