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Br J Cancer: 5-Aminosalicylic Acid: Candidate for Prevention of Colorectal Polyps and Colorectal Cancer

 Last Update: 2021-04-17
 Source: Internet
 Author: User

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Colorectal cancer (CRC) is one of the most common malignant tumors in the world.

Most CRC originates from the pre-tumor precursor lesions: colon polyps.

Screening prevention

Researchers use 5-ASA to treat human colorectal adenomas, transformed adenomas, and cancer cell lines to explore the growth of cells in two-dimensional and three-dimensional (3D) culture, the transcriptional activity of β-catenin, and the effect on tumor cell stem cells The impact of characteristics.

stem cell

5-ASA reduces the tumor ball-forming ability of PC/AA/C1 adenomas and LS174T cancer cells

All in all, the results of this study show that 5-ASA can inhibit the stem cell properties of adenoma-derived cells.

The affordable and well-tolerated 5-ASA is a potential drug candidate for chemoprevention, which can reduce the risk of colorectal polyps and CRC in high-risk populations.

org/10.

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