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Bone Marrow Transplant: Donor-derived anti-CD19 CAR-T cell therapy can safely and effectively treat B-ALL recurrence after allogeneic hematopoietic stem cell transplantation

 Last Update: 2021-05-20
 Source: Internet
 Author: User

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Currently, compared with DLI, the effectiveness and safety of donor-derived anti-CD19 CAR T cells in the treatment of relapsed B-cell acute lymphoblastic leukemia (B-ALL) after allogeneic hematopoietic stem cell transplantation (HSCT) remains unclear.

stem cell

In the study, 13 B-ALL patients relapsed after allogeneic hematopoietic stem cell transplantation and received donor-derived anti-CD19 CAR T cell therapy (study group), and 15 B-ALL patients relapsed after Allo-HSCT and received DLI Treatment (DLI group).

The results showed that the MRD-negative complete remission rate (61.

In summary, this study shows that donor-derived anti-CD19 CAR T cell therapy is a safe and effective therapy for B-ALL recurrence after allogeneic hematopoietic stem cell transplantation, and may be superior to DLI.

Original source:

Jingsheng Hua, et al.

ncbi.
nlm.
nih.
gov/33235353/" target="_blank" rel="noopener">Donor-derived anti-CD19 CAR T cells compared with donor lymphocyte infusion for recurrent B-ALL after allogeneic hematopoietic stem cell transplantation

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